NOTCH3 antibody (Alexa Fluor 647)

Catalog No. ABIN2657987

Product Details anti-NOTCH3 Antibody (Alexa Fluor 647)

Target: NOTCH3 (Notch 3 (NOTCH3))

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This NOTCH3 antibody is conjugated to Alexa Fluor 647

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.

Clone: HMN3-133

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C

Target Details for NOTCH3

Target: NOTCH3 (Notch 3 (NOTCH3))

Alternative Name: Notch 3 (NOTCH3 Products)

Synonyms: CADASIL antibody, CASIL antibody, IMF2 antibody, AW229011 antibody, N3 antibody, hpbk antibody, fa14b08 antibody, notch5 antibody, wu:fa14b08 antibody, notch 3 antibody, NOTCH3 antibody, Notch3 antibody, notch3 antibody

Background: The Notch receptors are highly conserved from invertebrates to mammals.While Notch1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences.The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus.This translocation triggers a series of signaling process.Notch 3 is primarily expressed in adult arterial smooth muscle cells.Notch 3 gene mutation can cause CADASIL, an inherited early stroke syndrome.

Pathways: Notch Signaling