SIGLEC9 antibody (APC)

Catalog No. ABIN2658391

Product Details anti-SIGLEC9 Antibody (APC)

Target: SIGLEC9 (Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIGLEC9 antibody is conjugated to APC

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Intracellular Flow Cytometry (ICFC)

Purification: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.

Clone: K8

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for SIGLEC9

Target: SIGLEC9 (Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9))

Alternative Name: Siglec-9 (SIGLEC9 Products)

Synonyms: CD329 antibody, CDw329 antibody, FOAP-9 antibody, OBBP-LIKE antibody, siglec-9 antibody, siglec9 antibody, sialic acid binding Ig like lectin 9 antibody, sialic acid-binding immunoglobulin-like lectin 9 antibody, SIGLEC9 antibody

Background: Siglecs are cell surface receptors belonging to the immunoglobulin superfamily that recognize sugar antigens. The extracellular domain of siglec-9 contains an IgV region, which binds sialic acid, followed by two IgC regions. Siglec 9 and siglec 6-8,10-12 are CD33 (siglec 3) like siglecs, which have two ITIMs in the cytoplasmic tails, suggesting their functional involvement in signal transduction. It is highly expressed on neutrophils and monocytes, and at lower levels on the subpopulations of T and B lymphocytes and NK cells. Siglec-9 plays a role in negative regulation of T cell activation, and it also affects neutrophil apoptosis.