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CSF1R antibody (APC)

CSF1R Reactivity: Mouse FACS, CyTOF Host: Rat Monoclonal AFS98 APC
Catalog No. ABIN2658445
  • Target See all CSF1R Antibodies
    CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
    Reactivity
    • 192
    • 135
    • 97
    • 17
    • 8
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Mouse
    Host
    • 224
    • 20
    • 9
    • 3
    • 2
    Rat
    Clonality
    • 226
    • 31
    • 1
    Monoclonal
    Conjugate
    • 93
    • 27
    • 15
    • 14
    • 13
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CSF1R antibody is conjugated to APC
    Application
    • 174
    • 106
    • 81
    • 67
    • 50
    • 26
    • 24
    • 20
    • 12
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Cytometry by Time of Flight (CyTOF)
    Purification
    The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
    Clone
    AFS98
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product CSF1R Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.2 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Protect from prolonged exposure to light. Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))
    Alternative Name
    CD115 (CSF1R Products)
    Synonyms
    AI323359 antibody, CD115 antibody, CSF-1R antibody, Csfmr antibody, Fim-2 antibody, Fms antibody, M-CSF-R antibody, M-CSFR antibody, C-FMS antibody, CSFR antibody, FIM2 antibody, FMS antibody, HDLS antibody, PDGFRB antibody, MGC89146 antibody, CSF-1-R antibody, c-fms antibody, mrfms antibody, CSF1 antibody, M-CSF antibody, csf1r antibody, fms antibody, panther antibody, colony stimulating factor 1 receptor antibody, macrophage colony-stimulating factor receptor antibody, colony stimulating factor 1 receptor, a antibody, Csf1r antibody, CSF1R antibody, m-csfr antibody, csf1r antibody, csf1ra antibody
    Background
    CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
    Pathways
    RTK Signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
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