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ICOS antibody (PE-Cy5)

ICOS Reactivity: Mouse CyTOF, ELISA (Capture) Host: Hamster Monoclonal 15F9 PE-Cy5
Catalog No. ABIN2658951
  • Target See all ICOS Antibodies
    ICOS (Inducible T-Cell Co-Stimulator (ICOS))
    Reactivity
    • 87
    • 23
    • 23
    • 6
    Mouse
    Host
    • 76
    • 17
    • 2
    • 1
    Hamster
    Clonality
    • 73
    • 23
    Monoclonal
    Conjugate
    • 39
    • 13
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ICOS antibody is conjugated to PE-Cy5
    Application
    • 64
    • 35
    • 33
    • 24
    • 14
    • 13
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    Cytometry by Time of Flight (CyTOF), ELISA (Capture)
    Purification
    The antibody was purified by affinity chromatography, and conjugated with PE/Cy5 under optimal conditions. The solution is free of unconjugated PE/Cy5 and unconjugated antibody.
    Clone
    15F9
    Isotype
    IgG
    Top Product
    Discover our top product ICOS Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.2 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Protect from prolonged exposure to light. Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    ICOS (Inducible T-Cell Co-Stimulator (ICOS))
    Alternative Name
    CD278 (ICOS Products)
    Synonyms
    ICOS antibody, AILIM antibody, CCLP antibody, CRP-1 antibody, H4 antibody, Ly115 antibody, CD278 antibody, CVID1 antibody, Ailim antibody, inducible T-cell costimulator antibody, inducible T cell co-stimulator antibody, inducible T-cell co-stimulator antibody, ICOS antibody, LOC100232284 antibody, Icos antibody
    Background
    CD278 is a 47-57 kD protein, also known as inducible costimulatory molecule (ICOS), or H4. This protein is homologous to the CD28/CTLA-4 proteins. It forms homodimers and is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. It has also been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.
    Pathways
    Cancer Immune Checkpoints
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