CD40 Ligand (CD40LG) antibody

Details for Product No. ABIN266058
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Antigen
Reactivity
Human
(265), (148), (32), (9), (5), (3), (3), (1)
Host
Mouse
(149), (96), (92), (20), (13), (12)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(53), (35), (29), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(221), (145), (96), (44), (42), (37), (27), (23), (18), (10), (7), (6), (4), (4), (3), (3), (3), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.05 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN266058
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Immunogen Human CD40L (CD154) transfected 300-19 cell (Mouse pre-B cell line).
Clone 5F3
Isotype IgG1
Specificity This reacts with CD40L (CD154) on cells from human origin in Flow Cytometry.
Cross-Reactivity (Details) Not yet tested in other species.
Purification Protein A purified
Alternative Name CD154 / CD40L
Background CD40 ligand (CD40L) is a 33 kDa type II membrane glycoprotein expressed mainly onthe cell surface of activated T lymphocytes, but also exists as a soluble formextracellularly. CD40L is the ligand for CD40, a member of the TNF superfamily, whichis expressed on the cell surface of B cells, macrophages/monocytes, dendritic cells,vascular endothelial cells, and epithelial cells. CD40L plays an important role in B cellproliferation, antibody class switching, modulation of apoptosis in the germinal centerthrough interaction with B cells expressing CD40, and activation of CD4+ T cells.Mutation within the CD40L gene is linked to hyper IgM syndrome, an X linkedimmunodeficiency disease that is characterized by elevated level of serum IgM anddecreased level of other isotypes. Alternate Names: anti-CD 154 antibody, anti-CD 40L antibody, anti-CD154 antibody, anti-CD154 antigenantibody, anti-CD40 antigen ligand antibody, anti-CD40 homologue antibody, anti-CD40L antibody, anti-CD40 ligand antibody, anti-CD40LG antibody, anti-gp39 antibody,anti-hCD40L antibody, anti-HIGM1 antibody, anti-Hyper IgM syndrome antibody,anti-IGM antibody, anti-IMD3 antibody, anti-Ly62 antibody, anti-T B cell activatingmolecule antibody, anti-T BAM antibody, anti-T cell antigen GP39 antibody, anti-TBAMantibody, anti-TNF related activation protein antibody, anti-TNF superfamily member 5antibody, anti-Tnfsf5 antibody, anti-TRAP antibody, anti-Tumor necrosis factor (ligand)superfamily member 5 antibody.
Gene Symbol: CD40LG
Gene ID 959
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry Use at a concentration of 5 - 10 µg/ml. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS), pH 7.2 with 1 % sucrose.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Spriggs, Armitage, Strockbine et al.: "Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion." in: The Journal of experimental medicine, Vol. 176, Issue 6, pp. 1543-50, 1993 (PubMed).

Armitage, Fanslow, Strockbine et al.: "Molecular and biological characterization of a murine ligand for CD40." in: Nature, Vol. 357, Issue 6373, pp. 80-2, 1992 (PubMed).

Stout, Suttles: "The many roles of CD40 in cell-mediated inflammatory responses." in: Immunology today, Vol. 17, Issue 10, pp. 487-92, 1997 (PubMed).

Grant, Andersson, Neurath et al.: "A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3' enhancer." in: The EMBO journal, Vol. 15, Issue 23, pp. 6691-700, 1997 (PubMed).

Sattler, Woodrum, Galili et al.: "Concurrent treatment with renin-angiotensin system blockers and acetylsalicylic acid reduces nuclear factor kappaB activation and C-reactive protein expression in human carotid artery plaques." in: Stroke; a journal of cerebral circulation, Vol. 36, Issue 1, pp. 14-20, 2004 (PubMed).

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