CD40 ligand (CD40L) is a 33 kDa type II membrane glycoprotein expressed mainly onthe cell surface of activated T lymphocytes, but also exists as a soluble formextracellularly. CD40L is the ligand for CD40, a member of the TNF superfamily, whichis expressed on the cell surface of B cells, macrophages/monocytes, dendritic cells,vascular endothelial cells, and epithelial cells. CD40L plays an important role in B cellproliferation, antibody class switching, modulation of apoptosis in the germinal centerthrough interaction with B cells expressing CD40, and activation of CD4+ T cells.Mutation within the CD40L gene is linked to hyper IgM syndrome, an X linkedimmunodeficiency disease that is characterized by elevated level of serum IgM anddecreased level of other isotypes. Alternate Names: anti-CD 154 antibody, anti-CD 40L antibody, anti-CD154 antibody, anti-CD154 antigenantibody, anti-CD40 antigen ligand antibody, anti-CD40 homologue antibody, anti-CD40L antibody, anti-CD40 ligand antibody, anti-CD40LG antibody, anti-gp39 antibody,anti-hCD40L antibody, anti-HIGM1 antibody, anti-Hyper IgM syndrome antibody,anti-IGM antibody, anti-IMD3 antibody, anti-Ly62 antibody, anti-T B cell activatingmolecule antibody, anti-T BAM antibody, anti-T cell antigen GP39 antibody, anti-TBAMantibody, anti-TNF related activation protein antibody, anti-TNF superfamily member 5antibody, anti-Tnfsf5 antibody, anti-TRAP antibody, anti-Tumor necrosis factor (ligand)superfamily member 5 antibody.
Gene Symbol: CD40LG