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Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 143-158) antibody

Details for Product No. ABIN266066
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Antigen
Synonyms IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, AW046014, AW547018, trif
Epitope
AA 143-158
(18), (3), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(36), (10), (7), (4)
Host
Rabbit
(44), (2), (1)
Clonality
Polyclonal
Application
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
(46), (12), (10), (8), (4), (2), (1)
Pubmed 3 references available
Quantity 0.2 mL
Shipping to United States (Change)
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Catalog No. ABIN266066
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Immunogen This antibody was developed against a synthetic peptide corresponding to amino acids 143-158 of mouse TRIF (NP_778154).
Isotype IgG
Specificity The will cross-react with human TRIF, but additional bands may be seen.
Cross-Reactivity (Details) Cross reacts in Mouse. Human reactivity reported in the scientific literature (PMID: 23777661). rat,reactivity reported in scientific literature (PMID: 23447644)
Purification Whole antisera
Alternative Name TICAM1 / TRIF
Background TICAM (Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule-1) or TRIF(Toll/IL-1 receptor domain-containing adapter inducing IFN-beta) plays an essential rolein the MyD88-independent signaling of TLR3. Alternate Names: anti-TICAM1 antibody.
Gene Symbol: TICAM1
Gene ID 148022, 106759
NCBI Accession NP_778154
Application Notes The ~70 kD band detected by this antibody in western blot, corresponding to TRIF protein, is blocked by the immunizing peptide.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:10-1:100, Western Blot 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.05 % BSA, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Supplier Images
anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (AA 143-158) antibody Western blot analysis of TICAM in mouse spleen lysate using ABIN266066 at 1:1000 dilution.
General Hoebe, Du, Georgel et al.: "Identification of Lps2 as a key transducer of MyD88-independent TIR signalling." in: Nature, Vol. 424, Issue 6950, pp. 743-8, 2003 (PubMed).

Naiki, Michelsen, Zhang et al.: "Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling." in: The Journal of biological chemistry, Vol. 280, Issue 7, pp. 5491-5, 2005 (PubMed).

Chassin, Goujon, Darche et al.: "Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 7, pp. 4773-84, 2006 (PubMed).

Validation Images
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