TICAM1 antibody (Toll-Like Receptor Adaptor Molecule 1) (Internal Region)

Details for Product anti-TICAM1 Antibody No. ABIN266066, Supplier: Log in to see
  • IIAE6
  • MyD88-3
  • TICAM-1
  • TRIF
  • AW046014
  • AW547018
  • trif
  • toll like receptor adaptor molecule 1
  • toll-like receptor adaptor molecule 1
  • TICAM1
  • Ticam1
  • ticam1
anti-Human TICAM1 antibody for Western Blotting
Internal Region
Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
This TICAM1 antibody is un-conjugated
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Simple Western (SimWes), Western Blotting (WB)
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Immunogen Synthetic peptide made to an internal portion of the mouse TRIF protein (between amino acids 100-180) [UniProt Q80UF7].
Specificity The will cross-react with human TRIF, but additional bands may be seen.
Purification Unpurified
Alternative Name TRIF/TICAM1 (TICAM1 Antibody Abstract)
Background Gene Symbol: TICAM1
Molecular Weight Theoretical MW: 76 kDa
Gene ID 148022
UniProt Q80UF7
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
Application Notes Western Blot 1:500-1:1000, Simple Western 1:100, Immunocytochemistry/Immunofluorescence 1:10-1:100, ImmunoprecipitationThe approx. 70 kD band detected by this antibody in western blot, corresponding to TRIF protein, is blocked by the immunizing peptide. In Simple Western only 10 - 15 μL of the recommended dilution is used per data point. Separated by Size-Wes, Sally Sue/Peggy Sue. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. Use in Immunoprecipitation reported in scientific literature (PMID 28007523).

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Buffer Whole antisera
Buffer contains: 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibody (ABIN266066) Western blot analysis of TICAM in mouse spleen lysate using ABIN266066 at 1:1000 dilu...
Simple Western (SimWes) image for anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibody (ABIN266066) Simple Western: TRIF/TICAM1 Antibody [ABIN2660660] - Simple Western lane view shows a...
Western Blotting (WB) image for anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibody (ABIN266066) Western Blot: TRIF/TICAM1 Antibody [ABIN2660660] - Analysis of TRIF in mouse A) intes...
Western Blotting (WB) image for anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibody (ABIN266066) Western Blot: TRIF/TICAM1 Antibody [ABIN2660660] - Analysis of TRIF in mouse spleen p...
Immunofluorescence (IF) image for anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) (Internal Region) antibody (ABIN266066) Immunocytochemistry/Immunofluorescence: TRIF/TICAM1 Antibody [ABIN2660660] - TRIF ant...
Product cited in: Kim, Beon, Lee, Park, Ahn, Kim, Park, Kim, Yuk, Kang, Lee, Jo, Seong, Kim: "Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6." in: Science advances, Vol. 3, Issue 4, pp. e1602296, 2017 (PubMed). Method employed by authors: Immunoprecipitation (IP) (Sample species: Mouse (Murine)).

Popiolek-Barczyk, Piotrowska, Makuch, Mika: "Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners." in: Neural plasticity, Vol. 2017, pp. 3829472, 2017 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).

Zhang, Xiang, Wang, Yan, Zhu, Guo, Sengupta, Chen, Loughran, Lu, Wang, Billiar et al.: "Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent ..." in: The Journal of biological chemistry, Vol. 291, Issue 29, pp. 15093-107, 2016 (PubMed). (Sample species: Mouse (Murine)). Further details: Western Blotting

Hu, Cong, Chen, Qi, Wu, Zhou, Yoo, Li, Sun, Wu, Zhao, Chen, Yu, Du, Wang: "Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway." in: Scientific reports, Vol. 6, pp. 23977, 2016 (PubMed). (Sample species: Pig (Porcine)). Further details: Western Blotting

Lan, Han, Li, Li, Gao, Cheng, Wan, Zhu, Wang: "Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia." in: Brain, behavior, and immunity, Vol. 61, pp. 326-339, 2016 (PubMed). Method employed by authors: Immunoprecipitation (IP) (Sample species: Mouse (Murine)).

Ma, Yu, Xie, Sun, Lin, Ding, Luo, Cai: "Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 30, pp. 10799-814, 2015 (PubMed). (Sample species: Mouse (Murine)). Further details: Immunocytochemistry,Immunofluorescence

Haque, Koide, Odkhuu, Tsolmongyn, Naiki, Komatsu, Yoshida, Yokochi: "Mouse pyrin and HIN domain family member 1 (pyhin1) protein positively regulates LPS-induced IFN-β and NO production in macrophages." in: Innate immunity, Vol. 20, Issue 1, pp. 40-8, 2013 (PubMed). (Sample species: Mouse (Murine)). Further details: Western Blotting

Vogt, Scull, Friling, Horwitz, Donovan, Dorner, Gerold, Labitt, Rice, Ploss: "Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines." in: Virology, Vol. 444, Issue 1-2, pp. 1-11, 2013 (PubMed). Further details: Western Blotting

Abe, Hirasaka, Kagawa, Kohno, Ochi, Utsunomiya, Sakai, Ohno, Teshima-Kondo, Okumura, Oarada, Maekawa, Terao, Mills, Nikawa: "Cbl-b is a critical regulator of macrophage activation associated with obesity-induced insulin resistance in mice." in: Diabetes, Vol. 62, Issue 6, pp. 1957-69, 2013 (PubMed).

Tian, Guo, Liu, Liu, Weng, Dong, Knowlton, Yuan, Lin: "Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes." in: Cardiovascular research, Vol. 98, Issue 3, pp. 391-401, 2013 (PubMed). (Sample species: Rat (Rattus)). Further details: Western Blotting

Seleme, Lei, Burg, Goh, Metz, Steele, Tse: "Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic mice." in: Free radical biology & medicine, Vol. 52, Issue 9, pp. 2047-56, 2012 (PubMed). Further details: Western Blotting

De Luca, Iannitti, Bozza, Beau, Casagrande, DAngelo, Moretti, Cunha, Giovannini, Massi-Benedetti, Carvalho, Boon, Latgé, Romani: "CD4(+) T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease." in: The Journal of clinical investigation, Vol. 122, Issue 5, pp. 1816-31, 2012 (PubMed). Further details: Western Blotting

Zhang, Kim, Bao, Facchinetti, Jung, Ghaffari, Qin, Cheng, Liu: "DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells." in: Immunity, Vol. 34, Issue 6, pp. 866-78, 2011 (PubMed).

Shi, Kehrl: "TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy." in: Science signaling, Vol. 3, Issue 123, pp. ra42, 2010 (PubMed). Further details: Western Blotting

Kong, Thimmulappa, Kombairaju, Biswal: "NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 1, pp. 569-77, 2010 (PubMed). (Sample species: Mouse (Murine)). Further details: Western Blotting

Wang, Kim, Nakahira, Ryter, Choi: "The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 6, pp. 3809-18, 2009 (PubMed). Further details: Western Blotting,Immunoprecipitation

Dasu, Park, Devaraj, Jialal: "Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice." in: Endocrinology, Vol. 150, Issue 8, pp. 3457-64, 2009 (PubMed). Further details: Western Blotting

Wong, Kwon, Choi, Kim, Nakahira, Hwang: "Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27384-92, 2009 (PubMed). Further details: Western Blotting

Shi, Kehrl: "MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages." in: The Journal of biological chemistry, Vol. 283, Issue 48, pp. 33175-82, 2008 (PubMed). Further details: Western Blotting

Krikun, Lockwood, Abrahams, Mor, Paidas, Guller: "Expression of Toll-like receptors in the human decidua." in: Histology and histopathology, Vol. 22, Issue 8, pp. 847-54, 2007 (PubMed). (Sample species: Human). Further details: Western Blotting

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