Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibody

Antigen: Toll-Like Receptor Adaptor Molecule 1 (TICAM1)

Synonyms: TRIF, PRVTIRB, TICAM-1, MGC35334

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN266066

Additional Information

Alternative name: TICAM1 / TRIF

Gene ID: 148022, 106759

Immunogen: This antibody was developed against a synthetic peptide corresponding to amino acids143-158 of mouse TICAM.

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Format: Serum

Isotype: IgG

Description: TICAM (Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule-1) or TRIF(Toll/IL-1 receptor domain-containing adapter inducing IFN-beta) plays an essential rolein the MyD88-independent signaling of TLR3. Alternate Names: anti-TICAM1 antibody.

Specificity: The antibody will cross-react with human TICAM, but additional bands may be seen. Species Reactivity: Cross-reacts with Human, Mouse and Rat. Not yet tested in other species.

Application Details

Application Notes: Suggested working dilutions: Western Blot 1/500 - 1/1000. Positive Controls: mouse spleen

Purification: Serum

Buffer: PBS containing 0.2% gelatin. Preservative: 0.05% Sodium Azide.

Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.

Restrictions: For Research Use only

Images

Western blot analysis of TICAM in mouse spleen lysate using ABIN266066 at 1:1000 dilution.

Publications

Hoebe, Du, Georgel et al.: "Identification of Lps2 as a key transducer of MyD88-independent TIR signalling." in: Nature, Vol. 424, Issue 6950, pp. 743-8, 2003 (PubMed).

Naiki, Michelsen, Zhang et al.: "Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling." in: The Journal of biological chemistry, Vol. 280, Issue 7, pp. 5491-5, 2005 (PubMed).

Chassin, Goujon, Darche et al.: "Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 7, pp. 4773-84, 2006 (PubMed).