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- Target See all ICOS Antibodies
- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
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Reactivity
- Mouse
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- This ICOS antibody is conjugated to Biotin
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Application
- Flow Cytometry (FACS)
- Characteristics
- The 7E.17G9 antibody reacts with the 47-57 kD ICOS protein, also known as inducible costimulatory molecule, and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes and can costimulate T cells and induce proliferation. In addition ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand, B7h/B7RP-1 and B7-H2 is constitutively expressed in B cell areas of secondary lymphoid organs and can be induced in other tissues by LPS. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. ICOS stimulation has been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.
- Purification
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
- Clone
- 7E-17G9
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product ICOS Primary Antibody
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anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 21-140) antibody
ICOS Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 156-185) antibodyICOS Reactivity: Human WB, IHC, FACS, ELISA Host: Rabbit Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 156-185), (C-Term) antibodyICOS Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB2237 unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (Internal Region) antibodyVerified ICOS Reactivity: Human IHC, ELISA Host: Goat Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) antibodyICOS Reactivity: Human, Mouse, Rat IF Host: Rabbit Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 21-200) antibodyICOS Reactivity: Human, Mouse, Rat WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) antibodyICOS Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 1-199) antibodyICOS Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) (AA 21-140) antibodyICOS Reactivity: Human WB, ELISA Host: Mouse Monoclonal 3G4 unconjugated
anti-Inducible T-Cell Co-Stimulator (ICOS) antibodyICOS Reactivity: Human IHC, FACS, IP, IHC (fro) Host: Mouse Monoclonal ISA-3 unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Do not freeze.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
- Alternative Name
- CD278 (ICOS Products)
- Pathways
- Cancer Immune Checkpoints
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