Interleukin 33 antibody (IL33) (Ser109) (Biotin)

Details for Product anti-IL33 Antibody No. ABIN2661329, Supplier: Log in to see
Antigen
  • IL33
  • C9orf26
  • DVS27
  • IL1F11
  • NF-HEV
  • NFEHEV
  • RP11-575C20.2
  • 9230117N10Rik
  • Il-33
  • Il1f11
  • RGD1311155
  • interleukin 33
  • interleukin 33-like
  • interleukin-33-like
  • IL33
  • Il33
  • LOC100356081
  • LOC100518643
Alternatives
anti-Mouse (Murine) Interleukin 33 antibody for Immunofluorescence (fixed cells)
Epitope
Ser109
68
26
20
15
12
7
6
5
5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
290
105
44
8
4
3
2
2
Host
Goat
188
133
23
23
4
3
2
1
1
Clonality (Clone)
Polyclonal ()
Conjugate
This Interleukin 33 antibody is conjugated to Biotin
35
19
14
14
8
7
5
5
5
4
4
4
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
279
215
89
60
45
24
21
21
16
14
13
11
7
5
5
4
3
3
2
2
2
1
1
Options
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Immunogen Ser109-Isoleucin266 (Accession# NM_133775) was expressed in E. coli.
Clone Poly5165
Isotype Ig Fraction, IgG
Cross-Reactivity Rat (Rattus)
Purification The antibody was purified by antigen affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
Alternative Name IL-33 (IL33 Antibody Abstract)
Background IL-33 belongs to the IL-1 family and is closely related in structure to IL-18 and IL-1b. IL-33, IL-1b, and IL-18 are synthesized as biologically inactive precursor and are cleaved by the enzyme caspase-1 to be secreted as active mature forms. IL-33 stimulates target cells by binding to the IL-1R/TLR superfamily member ST2 and subsequently activates NF-κB and MAPK pathways via identical signalling events to those observed for IL-1b. In addition, IL-33 is a nuclear factor (NF-HEV) abundantly expressed in high endothelial venules from lymphoid organs that associates with chromatin and exhibits transcriptional regulatory properties.
Pathways Production of Molecular Mediator of Immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.2 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 1 % BSA and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.
Supplier Images
ELISA image for anti-Interleukin 33 antibody (IL33) (Ser109) (Biotin) (ABIN2661329) anti-Interleukin 33 (IL33) (Ser109) antibody (Biotin)
Background publications Gao, Wang, Yang, Zhao, Wen, Li, Lu, Qin, Qi, Xie, Jiang, Wu, Zhang, Chen, Turnquist, Zhu, Lu: "Tumoral expression of IL-33 inhibits tumor growth and modifies the tumor microenvironment through CD8+ T and NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 1, pp. 438-45, 2014 (PubMed).

Arend, Palmer, Gabay: "IL-1, IL-18, and IL-33 families of cytokines." in: Immunological reviews, Vol. 223, pp. 20-38, 2008 (PubMed).

Moussion, Ortega, Girard: "The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?" in: PLoS ONE, Vol. 3, Issue 10, pp. e3331, 2008 (PubMed).

Suzukawa, Iikura, Koketsu, Nagase, Tamura, Komiya, Nakae, Matsushima, Ohta, Yamamoto, Yamaguchi: "An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 9, pp. 5981-9, 2008 (PubMed).

Schmitz, Owyang, Oldham, Song, Murphy, McClanahan, Zurawski, Moshrefi, Qin, Li, Gorman, Bazan, Kastelein: "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines." in: Immunity, Vol. 23, Issue 5, pp. 479-90, 2005 (PubMed).