TNFRSF13C antibody (Tumor Necrosis Factor Receptor Superfamily, Member 13C) (FITC)

Details for Product anti-TNFRSF13C Antibody No. ABIN2661625, Supplier: Log in to see
Antigen
  • RGD1560810
  • TNFRSF13C
  • BAFF-R
  • BAFFR
  • BROMIX
  • CD268
  • CVID4
  • prolixin
  • 2010006P15Rik
  • Baffr
  • Bcmd
  • Bcmd-1
  • Bcmd1
  • Lvis22
  • tumor necrosis factor receptor superfamily, member 13C
  • tumor necrosis factor receptor superfamily, member 13c
  • tumor necrosis factor receptor superfamily member 13C-like
  • TNFRSF13C
  • Tnfrsf13c
  • LOC618516
Alternatives
anti-Human TNFRSF13C antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
147
104
41
5
2
2
2
2
1
Host
Mouse
91
70
60
3
Clonality (Clone)
Monoclonal ()
Conjugate
This TNFRSF13C antibody is conjugated to FITC
19
12
11
8
8
5
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF), Intracellular Flow Cytometry (ICFC), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
123
85
65
43
41
13
8
8
6
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4
4
3
2
1
1
1
Options
Supplier
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Supplier Product No.
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Clone 11C1
Isotype IgG1 kappa
Purification The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Alternative Name CD268 (TNFRSF13C Antibody Abstract)
Background B cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF-R is the major receptor for BAFF/BLys (or TALL-1, THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-R promotes NF-κB activation and plays predominant roles in B-cell maturation and survival as well as costimulates T cell activation and proliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediated NF-κB activation.
Pathways NF-kappaB Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.
Supplier Images
Flow Cytometry (FACS) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C) antibody (FITC) (ABIN2661625) anti-Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C) antibody (FITC)
Background publications Rodig, Shahsafaei, Li, Mackay, Dorfman: "BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders." in: Human pathology, Vol. 36, Issue 10, pp. 1113-9, 2005 (PubMed).

Ye, Wang, Wells, Tao, Han, Davidson, Scott, Hancock: "BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses." in: European journal of immunology, Vol. 34, Issue 10, pp. 2750-9, 2004 (PubMed).

Ng, Sutherland, Newton, Qian, Cachero, Scott, Thompson, Wheway, Chtanova, Groom, Sutton, Xin, Tangye, Kalled, Mackay, Mackay: "B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 2, pp. 807-17, 2004 (PubMed).

Thompson, Bixler, Qian, Vora, Scott, Cachero, Hession, Schneider, Sizing, Mullen, Strauch, Zafari, Benjamin, Tschopp, Browning, Ambrose: "BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF." in: Science (New York, N.Y.), Vol. 293, Issue 5537, pp. 2108-11, 2001 (PubMed).

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