CD93 antibody (FITC)

Catalog No. ABIN2661864

Product Details anti-CD93 Antibody (FITC)

Target: CD93

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD93 antibody is conjugated to FITC

Application: Cytometry by Time of Flight (CyTOF), ELISA (Capture)

Purification: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.

Clone: AA4-1

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CD93

Target: CD93

Alternative Name: CD93 (CD93 Products)

Synonyms: 6030404G09Rik antibody, AA145088 antibody, AA4.1 antibody, AW555904 antibody, C1qr1 antibody, C1qrp antibody, Ly68 antibody, C1QR1 antibody, C1qR(P) antibody, C1qRP antibody, CDw93 antibody, ECSM3 antibody, MXRA4 antibody, dJ737E23.1 antibody, C1qRp antibody, CD93 antigen antibody, CD93 molecule antibody, Cd93 antibody, CD93 antibody

Target Type: Chemical

Background: CD93 is a 130-140 kD C-type lectin-like type I transmembrane protein, also known as complement component 1, q subcomponent (C1qR1), C1qRp collectin receptor (C1qRp), or AA4 antigen. It is a receptor expressed on immature B lymphocytes, hematopoietic progenitors and stem cells in adult bone marrow, fetal liver, and embryonic yolk sac. CD93 expression levels on splenic immature/transitional B cells is much lower than in bone marrow. It is reinduced during plasma cell differentiation and plays an important role in maintaining plasma cells in bone marrow niches. Immature dendritic cells express CD93 and down-regulate this molecule upon maturation, suggesting a role in uptake of particles by DC. It is also expressed on monocytes, macrophages, and endothelial cells. Macrophages from CD93 (-/-) mice had a significant phagocytic defect in the clearance of apoptotic cells in vivo, indicating CD93 may contribute to the in vivo clearance of dying cells. Binding of CD93 to C1q remains controversial.