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IL4 Receptor antibody (PE)

IL4R Reactivity: Mouse ELISA Host: Rat Monoclonal I015F8 PE
Catalog No. ABIN2662431
  • Target See all IL4 Receptor (IL4R) Antibodies
    IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
    Reactivity
    • 53
    • 37
    • 22
    Mouse
    Host
    • 67
    • 9
    • 2
    • 2
    • 1
    Rat
    Clonality
    • 72
    • 8
    • 1
    Monoclonal
    Conjugate
    • 44
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This IL4 Receptor antibody is conjugated to PE
    Application
    • 74
    • 25
    • 23
    • 15
    • 14
    • 13
    • 9
    • 7
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    ELISA
    Purification
    The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
    Clone
    I015F8
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product IL4R Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.2 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Protect from prolonged exposure to light. Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
    Alternative Name
    CD124 (IL4R Products)
    Synonyms
    IL4R antibody, il-4ra antibody, zgc:113063 antibody, CD124 antibody, IL-4RA antibody, IL4RA antibody, Il4ra antibody, IL4 antibody, Il4r antibody, interleukin 4 receptor antibody, interleukin 4 receptor, tandem duplicate 1 antibody, interleukin 4 receptor, alpha antibody, IL4R antibody, il4r.1 antibody, Il4r antibody, Il4ra antibody
    Background
    CD124, a subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common γ-chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL-4 or IL-13. A truncated form of IL-4Rα exists in soluble form in biological fluids. CD124 is expressed on mouse late precursors and mature B cells, T cells, monocytes, and has low expression on granulocytes. In B cells, CD124 can bind IL-4 and IL-13 and regulate IgE antibody production. In T cells, the type I IL-4R (IL-4R/gC) is mostly responsible for Th2 cell expansion by mediating IL-4-dependent activation of the transcription factors in hematopoietic cells. The type II IL-4R (IL-4R/IL-13Ra1) is the main route for nonhematopoietic cell responses to IL-4 or IL-13.
    Pathways
    JAK-STAT Signaling, Positive Regulation of Immune Effector Process
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