LILRB4
(Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4))
Reactivity
Mouse
Host
Armenian Hamster
Clonality
Monoclonal
Conjugate
This LILRB4 antibody is conjugated to PE
Application
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
CD85K antibody, ILT-3 antibody, ILT3 antibody, LIR-5 antibody, LIR5 antibody, Gp49b antibody, HM18 antibody, gp49 antibody, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 antibody, leukocyte immunoglobulin like receptor B4 antibody, leukocyte immunoglobulin-like receptor, subfamily B, member 4A antibody, LILRB4 antibody, Lilrb4a antibody
Background
Gp49, also known as ILT3, gp49b1 or CD85k, is a 49 kD glycoprotein expressed on activated NK cells and myeloid cells. It structurally resembles killer inhibitory receptors (KIR). gp49B is a type I membrane protein belonging to the Ig superfamily and contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), while gp49A is a truncated molecule without ITIM. Upon activation following interaction with integrin a vb3, the cytoplasmic tail associates with SHP-1 and SHP-2, which results in downregulation of cell activation and cytokine production.