CXCL9 antibody (PE)

Catalog No. ABIN2662706

Product Details anti-CXCL9 Antibody (PE)

Target: CXCL9 (gamma-Interferon-Induced Monokine (CXCL9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CXCL9 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Clone: J1015E10

Isotype: IgG2a kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CXCL9

Target: CXCL9 (gamma-Interferon-Induced Monokine (CXCL9))

Alternative Name: CXCL9 (CXCL9 Products)

Synonyms: CMK antibody, Humig antibody, MIG antibody, SCYB9 antibody, crg-10 antibody, BB139920 antibody, Mig antibody, MuMIG antibody, Scyb9 antibody, C-X-C motif chemokine ligand 9 antibody, chemokine (C-X-C motif) ligand 9 antibody, CXCL9 antibody, Cxcl9 antibody

Background: Chemokine (C-X-C motif) ligand 9 (CXCL9), also known as monokine induced by gamma interferon (MIG), is a small cytokine belonging to the non-ELR (lacking a Glu-Leu-Arg motif in the N-terminal region) motif CXC chemokines. CXCL9 is one of the ligands to share its receptor, CXCR3, with other two CXC chemokine family members, CXCL10 and CXCL11, through different binding fashions. The rank order of binding affinity is CXCL11>CXCL10>CXCL9. Some studies have revealed that these ligands have redundant functions in vivo, other studies have demonstrated that the three CXCR3 ligands can collaborate and even compete with each other. CXCL9 is mainly produced by activated macrophages and some cancer cells. Functioning as a chemoattractant, CXCL9 attracts CXCR3-expressing cells (such as a subset of circulating T cells, B cells, and natural killer cells) into inflammatory sites. Like other chemokines, CXCL9 is also able to elicit intracellular calcium flux and activate PI3K and MAPK. It participates in multiple immune and inflammatory responses by affecting cell growth, movement, or activation.