SIRPB1 antibody (PE)

Catalog No. ABIN2663095

Product Details anti-SIRPB1 Antibody (PE)

Target: SIRPB1 (Signal-Regulatory Protein beta 1 (SIRPB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIRPB1 antibody is conjugated to PE

Application: Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)

Characteristics: The B4B6 antibody recognizes human CD172b also known as signal-regulatory protein beta, and SIRP-beta. CD172b is a member of the signal regulatory protein family and immunoglobulin superfamily. CD172b contains a single pass transmembrane region with immunoglobulin-like domains and unlike CD172a, this receptor lacks a cytoplasmic SHP-2 binding domain. CD172b is a disulfide-linked homodimer with a predicted molecular weight of approximately 43 kD. Two isoforms of CD172b are produced by alternative splicing. CD172b is expressed on myeloid cells including monocytes and dendritic cells where it functions in the negative regulation of tyrosine-kinase coupled signaling processes. CD172b has been shown to regulate neutrophil transepithelial migration. CD172b interacts with DAP12 and Syk kinase (through TYROBP). The B4B6 antibody has been shown to be useful for flow cytometry.

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Clone: B4B6

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for SIRPB1

Target: SIRPB1 (Signal-Regulatory Protein beta 1 (SIRPB1))

Alternative Name: CD172b (SIRPB1 Products)

Synonyms: CD172b antibody, SIRP-BETA-1 antibody, SIRPB1 antibody, SIRPG antibody, signal regulatory protein beta 1 antibody, signal-regulatory protein beta-1 antibody, signal-regulatory protein beta-1 isoform 3 antibody, SIRPB1 antibody, LOC458036 antibody, LOC458430 antibody, LOC485809 antibody, LOC715912 antibody, LOC100458151 antibody