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TNF alpha antibody (PE)

TNF alpha Reactivity: Human FACS Host: Mouse Monoclonal MAb11 PE
Catalog No. ABIN2663940
  • Target See all TNF alpha Antibodies
    TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))
    Reactivity
    • 324
    • 182
    • 123
    • 67
    • 50
    • 42
    • 27
    • 26
    • 23
    • 16
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    • 10
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    • 5
    • 2
    • 2
    • 1
    • 1
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    • 1
    Human
    Host
    • 262
    • 193
    • 31
    • 25
    • 6
    • 2
    • 2
    Mouse
    Clonality
    • 278
    • 234
    Monoclonal
    Conjugate
    • 249
    • 86
    • 45
    • 20
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    • 6
    • 6
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    • 3
    • 3
    • 3
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    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TNF alpha antibody is conjugated to PE
    Application
    • 348
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    • 129
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    • 74
    • 62
    • 58
    • 49
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    • 40
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    • 32
    • 20
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    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Cross-Reactivity
    Chimpanzee, Baboon, Cynomolgus, Rhesus Monkey, Pig (Porcine), Pigtailed Macaque, Sooty mangabey (Cercocebus atys)
    Purification
    The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
    Clone
    MAb11
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product TNF alpha Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Protect from prolonged exposure to light. Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))
    Alternative Name
    TNF-alpha (TNF alpha Products)
    Synonyms
    DIF antibody, TNF-alpha antibody, TNFA antibody, TNFSF2 antibody, RATTNF antibody, Tnfa antibody, tnf antibody, TNF-a antibody, TNFalpha antibody, Tnfsf1a antibody, TNFa antibody, cTNF antibody, Tnf-alpha antibody, tnfa-like antibody, TNF-ALPHA antibody, dif antibody, tnfa antibody, xtnf antibody, tnfsf2 antibody, tnf-alpha antibody, Cachectin antibody, tumor necrosis factor antibody, tumor necrosis factor b (TNF superfamily, member 2) antibody, tumor necrosis factor alpha antibody, tumor necrosis factor a (TNF superfamily, member 2) antibody, TNF antibody, Tnf antibody, tnf antibody, tnfb antibody, tnf-alpha antibody, LOC103694380 antibody, tnfa antibody
    Background
    TNF-α is secreted by macrophages, monocytes, neutrophils, T cells (principally CD4+), and NK cells. Many transformed cell lines also secrete TNF-α. Monomeric human TNF-α is a 157 amino acid protein (non-glycosylated) with a reported molecular weight of 17 kD. TNF-α forms multimeric complexes, stable trimers are most common in solution. A 26 kD membrane form of TNF-α has also been described. TNF-α binding to surface receptors elicits a wide array of biological activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.
    Pathways
    NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Inflammasome
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