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IL2 Receptor beta antibody
IL2RB
Reactivity: Mouse
FACS
Host: Rat
Monoclonal
5H4
unconjugated
Product Details anti-IL2 Receptor beta Antibody
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Target
See all IL2 Receptor beta (IL2RB) Antibodies
IL2 Receptor beta (IL2RB)
(Interleukin 2 Receptor, beta (IL2RB))
Reactivity
All reactivities for IL2 Receptor beta antibodies
Mouse
Host
All hosts for IL2 Receptor beta antibodies
Rat
Clonality
All clonalities for IL2 Receptor beta antibodies
Monoclonal
Conjugate
All conjugates for IL2 Receptor beta antibodies
This IL2 Receptor beta antibody is un-conjugated
Application
All applications for IL2 Receptor beta antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography.
Clone
5H4
Isotype
IgG2a kappa
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for IL2 Receptor beta
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Target
IL2 Receptor beta (IL2RB)
(Interleukin 2 Receptor, beta (IL2RB))
Alternative Name
CD122 (IL2RB Products )
Synonyms
IL2RB antibody, il-2rb antibody, CD122 antibody, IL15RB antibody, P70-75 antibody, IL2RBC antibody, IL-15Rbeta antibody, IL15Rbeta antibody, Il-2/15Rbeta antibody, Il-2Rbeta antibody, p70 antibody, interleukin 2 receptor subunit beta antibody, interleukin-2 receptor subunit beta antibody, interleukin 2 receptor, beta antibody, interleukin 2 receptor, beta chain antibody, IL2RB antibody, LOC510185 antibody, il2rb antibody, Il2rb antibody
Target Type
Chemical
Background
CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit(CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.
Pathways
JAK-STAT Signaling , Growth Factor Binding
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