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FLT3 antibody
FLT3
Reactivity: Human
FACS
Host: Mouse
Monoclonal
BV10A4H2
unconjugated
Product Details anti-FLT3 Antibody
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Target
See all FLT3 Antibodies
FLT3
(Fms-Related tyrosine Kinase 3 (FLT3))
Reactivity
All reactivities for FLT3 antibodies
Human
Host
All hosts for FLT3 antibodies
Mouse
Clonality
All clonalities for FLT3 antibodies
Monoclonal
Conjugate
All conjugates for FLT3 antibodies
This FLT3 antibody is un-conjugated
Application
All applications for FLT3 antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography.
Clone
BV10A4H2
Isotype
IgG1 kappa
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for FLT3
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Target
FLT3
(Fms-Related tyrosine Kinase 3 (FLT3))
Alternative Name
CD135 (FLT3 Products )
Synonyms
FLT3 antibody, B230315G04 antibody, CD135 antibody, Flk-2 antibody, Flk2 antibody, Flt-3 antibody, Ly72 antibody, wmfl antibody, FLK-2 antibody, FLK2 antibody, STK1 antibody, fms related tyrosine kinase 3 antibody, FMS-like tyrosine kinase 3 antibody, fms-related tyrosine kinase 3 antibody, FLT3 antibody, Flt3 antibody
Background
CD135 is a 130-160 kD type III tyrosine kinase receptor expressed on CD34+ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML-BC. CD135, also known as FMS-like tyrosine kinase-3, FLT3, STK-1, and Flk-2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation and has been shown to interact with Grb2, SOCS1, VAV1, and Shc.
Pathways
RTK Signaling
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