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SIGLEC5 antibody
SIGLEC5
Reactivity: Human
ICFC
Host: Mouse
Monoclonal
1A5
unconjugated
Product Details anti-SIGLEC5 Antibody
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Target
See all SIGLEC5 Antibodies
SIGLEC5
(Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))
Reactivity
All reactivities for SIGLEC5 antibodies
Human
Host
All hosts for SIGLEC5 antibodies
Mouse
Clonality
All clonalities for SIGLEC5 antibodies
Monoclonal
Conjugate
All conjugates for SIGLEC5 antibodies
This SIGLEC5 antibody is un-conjugated
Application
All applications for SIGLEC5 antibodies
Intracellular Flow Cytometry (ICFC)
Cross-Reactivity
Chimpanzee, Bonobo, Gorilla
Purification
The antibody was purified by affinity chromatography.
Clone
1A5
Isotype
IgG1 kappa
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Discover our top product SIGLEC5 Primary Antibody
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for SIGLEC5
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Target
SIGLEC5
(Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))
Alternative Name
CD170 (SIGLEC5 Products )
Synonyms
CD170 antibody, CD33L2 antibody, OB-BP2 antibody, OBBP2 antibody, SIGLEC-5 antibody, sialic acid binding Ig like lectin 5 antibody, sialic acid-binding Ig-like lectin 5 antibody, sialic acid binding Ig-like lectin 5 antibody, SIGLEC5 antibody, LOC100597560 antibody, Siglec5 antibody
Background
CD170, also known as Siglec-5, is a single pass transmembrane protein member of the immunoglobulin superfamily. On the cell surface, CD170 forms a 140 kD dimer. The cytoplasmic domain of Siglec-5 contains two ITIM motifs that recruit the tyrosine-phosphatases SHP-1 and SHP-2 after tyrosine-phosphorylation, which in turn results in the inhibition of cell signaling. Siglec-5 is expressed by granulocytes, monocytes/macrophages, subsets of lymphocytes, and a subset of activated dendritic cells. Siglec-5 binds α2,3- and α2,6-linked sialic acid as well as glycophorin A, and is involved in cell adhesion.
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