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CD28 antibody

CD28 Reactivity: Human BCA Host: Mouse Monoclonal CD28-2 unconjugated
Catalog No. ABIN2664495
  • Target See all CD28 Antibodies
    CD28
    Reactivity
    • 173
    • 128
    • 58
    • 38
    • 21
    • 20
    • 12
    • 12
    • 7
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 126
    • 79
    • 33
    • 16
    • 8
    • 3
    • 2
    • 1
    Mouse
    Clonality
    • 188
    • 74
    • 3
    Monoclonal
    Conjugate
    • 88
    • 30
    • 29
    • 21
    • 14
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD28 antibody is un-conjugated
    Application
    • 199
    • 94
    • 47
    • 47
    • 38
    • 31
    • 27
    • 26
    • 19
    • 17
    • 13
    • 7
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    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Biochemical Assay (BCA)
    Cross-Reactivity
    Chimpanzee, Baboon, Cynomolgus, Rhesus Monkey, Pigtailed Macaque, Capuchin Monkey, Sooty mangabey (Cercocebus atys), Squirrel Monkey (Saimiri spec.)
    Purification
    The antibody was purified by affinity chromatography.
    Clone
    CD28-2
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD28 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and EDTA.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    CD28
    Alternative Name
    CD28 (CD28 Products)
    Synonyms
    Tp44 antibody, CD28RNA antibody, cd28 antibody, CD28 molecule antibody, CD28 antigen antibody, Cd28 molecule antibody, CD28 molecule L homeolog antibody, CD28 antibody, Cd28 antibody, cd28.L antibody
    Background
    CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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