CXCL16 antibody

Catalog No. ABIN2664903

Product Details anti-CXCL16 Antibody

Target: CXCL16 (Chemokine (C-X-C Motif) Ligand 16 (CXCL16))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CXCL16 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Purification: The antibody was purified by affinity chromatography.

Clone: 22-19-12

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CXCL16

Target: CXCL16 (Chemokine (C-X-C Motif) Ligand 16 (CXCL16))

Alternative Name: CXCL16 (CXCL16 Products)

Synonyms: CXCL16 antibody, 0910001K24Rik antibody, AV290116 antibody, BB024863 antibody, CXCL16v1 antibody, CXCL16v2 antibody, SR-PSOX antibody, Zmynd15 antibody, b2b498Clo antibody, CXCLG16 antibody, SRPSOX antibody, C-X-C motif chemokine ligand 16 antibody, chemokine (C-X-C motif) ligand 16 antibody, CXCL16 antibody, Cxcl16 antibody

Background: CXCL16, a 27 kD chemokine, exists in membrane-bound and soluble forms. Unlike classic chemokines, CXCL16 possesses a mucin-like stalk, a transmembrane domain, and a cytoplasmic tail with a tyrosine phosphorylation domain, allowing it to be expressed on the cell surface. Structurally, it is similar to fractalkine. It is expressed by dendritic cells, monocytes, and T cells. T cells can also migrate in response to CXCL16. CXCL16 can also act as a scavenger receptor on macrophages. Its receptor is CXCR6/Bonzo. It can bind oxidized LDL and thus may play an important role in atherosclerosis. Recent studies have shown a role for CXCL16 in kidney fibrosis and in autoimmunity. CXCL16 is also a co-receptor for HIV.