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Interleukin 17a antibody

IL17A Reactivity: Human BCA Host: Mouse Monoclonal BL168 unconjugated
Catalog No. ABIN2665116
  • Target See all Interleukin 17a (IL17A) Antibodies
    Interleukin 17a (IL17A) (Interleukin 17A (IL17A))
    Reactivity
    • 90
    • 42
    • 19
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    Human
    Host
    • 62
    • 40
    • 17
    • 7
    • 3
    Mouse
    Clonality
    • 71
    • 57
    • 1
    Monoclonal
    Conjugate
    • 63
    • 21
    • 15
    • 10
    • 8
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Interleukin 17a antibody is un-conjugated
    Application
    • 71
    • 61
    • 31
    • 14
    • 11
    • 11
    • 10
    • 10
    • 9
    • 8
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Biochemical Assay (BCA)
    Purification
    The antibody was purified by affinity chromatography.
    Clone
    BL168
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product IL17A Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and EDTA.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    Interleukin 17a (IL17A) (Interleukin 17A (IL17A))
    Alternative Name
    IL-17A (IL17A Products)
    Synonyms
    CTLA8 antibody, IL-17 antibody, IL-17A antibody, IL17 antibody, Ctla-8 antibody, Ctla8 antibody, Il17 antibody, ChIL-17 antibody, IL-17F antibody, IL17A antibody, CTLA-8 antibody, interleukin 17A antibody, IL17A antibody, Il17a antibody
    Background
    IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63 % , 63 %, and 72 % amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.
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