IL23 antibody

Catalog No. ABIN2665146

Product Details anti-IL23 Antibody

Target: IL23 (Interleukin 23 (IL23))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL23 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Intracellular Flow Cytometry (ICFC)

No Cross-Reactivity: Mouse (Murine)

Characteristics: The HLT2736 clone recognizes human IL-23, a heterodimeric cytokine composed of the p40 subunit shared with IL-12 and a specific p19 subunit. This antibody recognizes heterodimeric IL-23, but does not react with the p40 subunit alone or recombinant IL-12(p70) when used as a capture antibody in ELISA. IL-23 is secreted by activated dendritic cells and macrophages and has been shown to enhance IFN-γ secretion by memory (CD45RO) T cells in an IL-2 dependent manner. IL-23 may also induce unique Th subset (designated ThIL-17) that secretes the cytokines IL-17, IL-6, TNF and low levels of IFN-γ. IL-23 has been shown to promote immunity to mycobacteria and has been shown to be upregulated in response to some viral infections and in psoriatic lesions. IL-23 binds to the IL-23 receptor comprised of a β1 subunit shared with the IL-12 receptor and IL-23-specific subunit. This antibody has been shown to be useful for Western blotting and immunohistochemistry using formalin-fixed, paraffin embedded tissues with (catalyzed signal amplification).

Purification: The antibody was purified by affinity chromatography.

Clone: HLT2736

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for IL23

Target: IL23 (Interleukin 23 (IL23))

Alternative Name: IL-23 (IL23 Products)

Synonyms: IL-23 antibody, p19 antibody, SGRF antibody, il23p19 antibody, interleukin 23, alpha subunit p19 antibody, interleukin 23 subunit alpha antibody, Il23a antibody, IL23A antibody