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Plexin B2 antibody

PLXNB2 Reactivity: Mouse ICFC Host: Armenian Hamster Monoclonal 3E7 unconjugated
Catalog No. ABIN2665329
  • Target See all Plexin B2 (PLXNB2) Antibodies
    Plexin B2 (PLXNB2)
    Reactivity
    • 16
    • 4
    • 2
    Mouse
    Host
    • 14
    • 2
    • 1
    Armenian Hamster
    Clonality
    • 16
    • 1
    Monoclonal
    Conjugate
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Plexin B2 antibody is un-conjugated
    Application
    • 9
    • 8
    • 2
    • 2
    • 1
    • 1
    Intracellular Flow Cytometry (ICFC)
    Purification
    The antibody was purified by affinity chromatography.
    Clone
    3E7
    Isotype
    IgG
    Top Product
    Discover our top product PLXNB2 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    Plexin B2 (PLXNB2)
    Alternative Name
    Plexin B2 (PLXNB2 Products)
    Synonyms
    PLXNB2 antibody, MM1 antibody, Nbla00445 antibody, PLEXB2 antibody, dJ402G11.3 antibody, 1110007H23Rik antibody, Debt antibody, mKIAA0315 antibody, plexin B2 antibody, plexin B2 S homeolog antibody, PLXNB2 antibody, plxnb2.S antibody, plxnb2 antibody, Plxnb2 antibody
    Background
    Plexin B2 is a 240 kD transmembrane receptor belonging to the semaphorin receptor family, B subfamily. All the family members share an extracellular semaphorin domain and an intracellular plexin domain-containing tail that can mediate intracellular signaling. Distinct from the other subfamily members, Plexin B2 contains an intracellular domain with a PDZ motif (post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (DlgA), and zonula occludens-1 protein (zo-1)), which can relay extracellular signals to intracellular motifs. Similar to the other B family members, Plexin B2 was also originally found in the nervous system and was later reported on endocrine, reproductive, urinary, digestive, respiratory, and immune systems. In immune cells, Plexin B2 is highly expressed on macrophages, conventional dendritic cells (cDCs), and plasmacytoid dendritic cells (pDCs). It is also expressed on T cells and T-dependent germinal center B cells. Plexin B2 facilitates ligand induced cell guidance and migration in the nervous system, and induces cytoskeletal changes in overexpression assays through RhoGTPase. However, the function of Plexin B2 in the immune system is not conclusive. Plexin B2 has been reported to modulate upon activation of DCs by TLR ligands, TNF-α, and anti-CD40. It also functions as a negative regulator of Rac and Cdc42 and modulates cell motility in macrophages. Plexin B2 has been found to have several semaphorin ligands including Semaphorin-3E, Semaphorin-4A, Semaphorin-4C, and Semaphorin-4D.
    Pathways
    Tube Formation
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