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Thymic Stromal Lymphopoietin antibody (AA 29-159)

TSLP Reactivity: Human WB, ELISA (Capture) Host: Goat Polyclonal Poly5159 unconjugated
Catalog No. ABIN2665475
  • Target See all Thymic Stromal Lymphopoietin (TSLP) Antibodies
    Thymic Stromal Lymphopoietin (TSLP)
    Binding Specificity
    • 11
    • 9
    • 9
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 29-159
    Reactivity
    • 43
    • 9
    • 7
    • 2
    • 1
    • 1
    Human
    Host
    • 49
    • 4
    • 1
    Goat
    Clonality
    • 48
    • 5
    • 1
    Polyclonal
    Conjugate
    • 28
    • 7
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Thymic Stromal Lymphopoietin antibody is un-conjugated
    Application
    • 43
    • 17
    • 11
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA (Capture)
    Cross-Reactivity (Details)
    Not cross-reactive with recombinant mouse TSLP.
    Purification
    The antibody was purified by affinity chromatography.
    Immunogen
    AA 29-159 (Accession# AF338732), was expressed in E.coli.
    Clone
    Poly5159
    Isotype
    Ig Fraction, IgG
    Top Product
    Discover our top product TSLP Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    Thymic Stromal Lymphopoietin (TSLP)
    Alternative Name
    TSLP (TSLP Products)
    Synonyms
    TSLP antibody, thymic stromal lymphopoietin antibody, TSLP antibody, Tslp antibody
    Background
    TSLP was initially identified in conditioned medium from a mouse thymic stromal cell line. Human and mouse TSLP are only 43 % identical at the amino acid level, and TSLP, like IL-7, exhibits species-specific functions and may function differently in humans and mice. TSLP binds to a heterodimeric receptor constituted by IL-7Ra and TSLPR. TSLPR has low affinity for TSLP, but in combination with IL-7Ra generates a high affinity binding site. TSLP has been associated with the development of allergic disorders in humans, such as asthma, atopic dermatitis, and food allergies. The susceptibility to allergic diseases has been associated to basophil induction by TSLP, and Th2 cytokine production induced by TSLP in mast cells. In addition, TSLP has been associated to the development of Tregs, and blocking TSLPR leads to delayed functional maturation of thymic Tregs. TSLPR has been detected in Tregs from allergic asthmatic patients. TSLP directly activates STAT5 in Tregs and suppresses its suppressive activities, additionally, it inhibits IL-10 production. Human TSLP induces the release of T cell-attracting chemokines (CCL17 and CCL22) from monocytes and enhances the T cell stimulatory capacity of the CD11c+ subset of dendritic cells. TSLP induces proliferation of naive T cells. In addition, it can drive Th2 differentiation via the induction of IL-4 production, and drives Th2 cytokine-mediated inflammation by acting on bone marrow-resident progenitors, which promotes basophil hematopoiesis. TSLP is upregulated in epithelial cells by IL-1α, TNFα, and Th2 cytokines.
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