Interleukin 33 antibody (IL33) (AA 112-270)

Details for Product anti-IL33 Antibody No. ABIN2665497, Supplier: Log in to see
Antigen
  • IL33
  • C9orf26
  • DVS27
  • IL1F11
  • NF-HEV
  • NFEHEV
  • RP11-575C20.2
  • 9230117N10Rik
  • Il-33
  • Il1f11
  • RGD1311155
  • interleukin 33
  • interleukin 33-like
  • interleukin-33-like
  • IL33
  • Il33
  • LOC100356081
  • LOC100518643
Alternatives
anti-Human Interleukin 33 antibody for Blocking Antibody
Epitope
AA 112-270
67
26
20
15
12
7
6
5
5
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
289
106
45
8
4
3
2
2
Host
Goat
188
133
23
23
4
3
2
1
1
Clonality (Clone)
Polyclonal ()
Conjugate
This Interleukin 33 antibody is un-conjugated
36
19
14
14
8
7
5
5
5
4
4
4
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC)
279
215
88
60
45
24
21
21
16
14
13
11
7
5
5
4
3
3
2
2
2
1
1
Options
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Immunogen AA 112-270 (Accession# NM_033439) was expressed in E. coli.
Clone Poly5163
Isotype Ig Fraction, IgG
Cross-Reactivity (Details) In sandwich ELISA, no cross-reactivity with mouse or rat IL-33.
Purification The antibody was purified by antigen affinity chromatography.
Alternative Name IL-33 (IL33 Antibody Abstract)
Background IL-33, also known as NFHEV and DVS 27, is a 30 kD proinflammatory protein that belongs to IL-1 superfamily. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1α or IL-1β stimulation. IL-33 interacts with IL1RL1/ST2 receptor and IL-1 receptor accessory protein (IL1RAP) in order to activate intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. Recombinant IL-33 has been shown to enhance Th2-associated immune responses and potently increase mast cell proliferation and cytokine production.
Pathways Production of Molecular Mediator of Immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.
Supplier Images
ELISA image for anti-Interleukin 33 antibody (IL33) (AA 112-270) (ABIN2665497) anti-Interleukin 33 (IL33) (AA 112-270) antibody
Background publications McLaren, Michael, Salter, Ashlin, Calder, Miller, Liew, Ramji: "IL-33 reduces macrophage foam cell formation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 2, pp. 1222-9, 2010 (PubMed).

Schmitz, Owyang, Oldham, Song, Murphy, McClanahan, Zurawski, Moshrefi, Qin, Li, Gorman, Bazan, Kastelein: "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines." in: Immunity, Vol. 23, Issue 5, pp. 479-90, 2005 (PubMed).

Onda, Kasuya, Takakura, Hori, Imaizumi, Takeuchi, Inoue, Takeda: "Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 19, Issue 11, pp. 1279-88, 1999 (PubMed).