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IL-33 antibody (AA 112-270)

IL33 Reactivity: Human IHC, FACS Host: Goat Polyclonal Poly5163 unconjugated
Catalog No. ABIN2665497
  • Target See all IL-33 (IL33) Antibodies
    IL-33 (IL33) (Interleukin 33 (IL33))
    Binding Specificity
    • 19
    • 16
    • 10
    • 9
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 112-270
    Reactivity
    • 81
    • 46
    • 37
    • 9
    • 1
    Human
    Host
    • 102
    • 27
    • 4
    • 3
    • 2
    • 1
    • 1
    Goat
    Clonality
    • 110
    • 30
    Polyclonal
    Conjugate
    • 71
    • 21
    • 13
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL-33 antibody is un-conjugated
    Application
    • 84
    • 68
    • 34
    • 26
    • 19
    • 15
    • 14
    • 14
    • 12
    • 10
    • 9
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    Immunohistochemistry (IHC), Flow Cytometry (FACS)
    Cross-Reactivity (Details)
    In sandwich ELISA, no cross-reactivity with mouse or rat IL-33.
    Purification
    The antibody was purified by antigen affinity chromatography.
    Immunogen
    AA 112-270 (Accession# NM_033439) was expressed in E. coli.
    Clone
    Poly5163
    Isotype
    Ig Fraction, IgG
    Top Product
    Discover our top product IL33 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    IL-33 (IL33) (Interleukin 33 (IL33))
    Alternative Name
    IL-33 (IL33 Products)
    Synonyms
    IL33 antibody, C9orf26 antibody, DVS27 antibody, IL1F11 antibody, NF-HEV antibody, NFEHEV antibody, RP11-575C20.2 antibody, 9230117N10Rik antibody, Il-33 antibody, Il1f11 antibody, RGD1311155 antibody, interleukin 33 antibody, IL33 antibody, Il33 antibody
    Background
    IL-33, also known as NFHEV and DVS 27, is a 30 kD proinflammatory protein that belongs to IL-1 superfamily. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1α or IL-1β stimulation. IL-33 interacts with IL1RL1/ST2 receptor and IL-1 receptor accessory protein (IL1RAP) in order to activate intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. Recombinant IL-33 has been shown to enhance Th2-associated immune responses and potently increase mast cell proliferation and cytokine production.
    Pathways
    Production of Molecular Mediator of Immune Response
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