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IL-33 antibody (Ser109)
IL33
Reactivity: Mouse, Rat
WB, IHC, IP, IF
Host: Goat
Polyclonal
Poly5165
unconjugated
Product Details anti-IL-33 Antibody
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Target
See all IL-33 (IL33) Antibodies
IL-33 (IL33)
(Interleukin 33 (IL33))
Binding Specificity
All epitopes for IL-33 antibodies
Ser109
Reactivity
All reactivities for IL-33 antibodies
Mouse, Rat
Host
All hosts for IL-33 antibodies
Goat
Clonality
All clonalities for IL-33 antibodies
Polyclonal
Conjugate
All conjugates for IL-33 antibodies
This IL-33 antibody is un-conjugated
Application
All applications for IL-33 antibodies
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
Cross-Reactivity
Rat (Rattus)
Purification
The antibody was purified by antigen affinity chromatography.
Immunogen
Ser109-Isoleucin266 (Accession# NM_133775) was expressed in E. coli.
Clone
Poly5165
Isotype
Ig Fraction, IgG
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Discover our top product IL33 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for IL-33
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Target
IL-33 (IL33)
(Interleukin 33 (IL33))
Alternative Name
IL-33 (IL33 Products )
Synonyms
IL33 antibody, C9orf26 antibody, DVS27 antibody, IL1F11 antibody, NF-HEV antibody, NFEHEV antibody, RP11-575C20.2 antibody, 9230117N10Rik antibody, Il-33 antibody, Il1f11 antibody, RGD1311155 antibody, interleukin 33 antibody, IL33 antibody, Il33 antibody
Background
IL-33 belongs to the IL-1 family and is closely related in structure to IL-18 and IL-1b. IL-33, IL-1b, and IL-18 are synthesized as biologically inactive precursor and are cleaved by the enzyme caspase-1 to be secreted as active mature forms. IL-33 stimulates target cells by binding to the IL-1R/TLR superfamily member ST2 and subsequently activates NF-κB and MAPK pathways via identical signalling events to those observed for IL-1b. In addition, IL-33 is a nuclear factor (NF-HEV) abundantly expressed in high endothelial venules from lymphoid organs that associates with chromatin and exhibits transcriptional regulatory properties.
Pathways
Production of Molecular Mediator of Immune Response
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