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BAX antibody

BAX Reactivity: Human FACS Host: Mouse Monoclonal 2D2 unconjugated
Catalog No. ABIN2666258
  • Target See all BAX Antibodies
    BAX (BCL2-Associated X Protein (BAX))
    Reactivity
    • 257
    • 156
    • 143
    • 46
    • 31
    • 27
    • 25
    • 18
    • 17
    • 10
    • 9
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 168
    • 97
    • 4
    • 2
    Mouse
    Clonality
    • 181
    • 90
    Monoclonal
    Conjugate
    • 142
    • 16
    • 13
    • 13
    • 10
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BAX antibody is un-conjugated
    Application
    • 241
    • 114
    • 72
    • 64
    • 52
    • 52
    • 51
    • 43
    • 42
    • 14
    • 12
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Purification
    The antibody was purified by affinity chromatography.
    Clone
    2D2
    Isotype
    IgG1 kappa
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    Discover our top product BAX Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide at 0.5 mg/mL.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Upon receipt, store undiluted at between 2°C and 8°C.
  • Target
    BAX (BCL2-Associated X Protein (BAX))
    Alternative Name
    Bax (BAX Products)
    Synonyms
    BAX-ALPHA antibody, bax-A antibody, xBax antibody, xlbax antibody, BAX antibody, bax antibody, fj16e01 antibody, wu:fc50b10 antibody, wu:fj16e01 antibody, BCL2L4 antibody, zgc:112983 antibody, BCL2 associated X, apoptosis regulator antibody, BCL2-associated X protein L homeolog antibody, BCL2-associated X protein antibody, bcl2-associated X protein, a antibody, bcl2-associated X protein, b antibody, BAX antibody, bax.L antibody, bax antibody, baxa antibody, Bax antibody, baxb antibody
    Background
    Bax is a 21 kD pro-apoptotic protein known to regulate apoptosis. Bax is found in the cytoplasm, mitochondria, and nucleus and is highly expressed in hematopoietic stem cells, ovaries, and lymph nodes. Bax binds the anti-apoptotic protein Bcl-2 as a heterodimer or forms homodimers. The relative levels of pro-apoptotic proteins such as Bax and anti-apoptotic proteins such as Bcl-2 determines whether cell death will occur following an apoptotic stimulus. Bax accelerates the opening of mitochondrial VDAC altering membrane potential and allowing cytochrome c to pass out of the mitochondria into the cytosol to initiate downstream caspase activation. p53 can transcriptionally activate the Bax gene to induce apoptosis. Bax has been shown to be mutated in some human cancers.
    Pathways
    p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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