RAG2 antibody

Catalog No. ABIN2666293

Product Details anti-RAG2 Antibody

Target: RAG2 (Recombination Activating Gene 2 (RAG2))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This RAG2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purified.

Clone: 3G4A26

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Upon receipt, store undiluted between 2°C and 8°C.

Target Details for RAG2

Target: RAG2 (Recombination Activating Gene 2 (RAG2))

Alternative Name: RAG2 (RAG2 Products)

Synonyms: RAG-2 antibody, Rag-2 antibody, rag-2 antibody, zgc:136743 antibody, recombination activating 2 antibody, recombination activating gene 2 antibody, recombination activating gene 2 S homeolog antibody, RAG2 antibody, Rag2 antibody, rag2 antibody, rag2.S antibody

Background: During T cell and B cell development, RAG2 works together with RAG1 to induce DNA rearrangement and assembly of antigen receptor coding segments. Defects in RAG2 gene lead to the complete lack of mature T and B lymphocytes and result in severe combined immunodeficiency (SCID). RAG2 also functions in chromosome binding through its unique plant homeodomain (PHD). Sequestration of recombination signal sequences (RSS) within the nucleosome by RAG2 prevents access by the recombinase complex.

Pathways: Chromatin Binding, Production of Molecular Mediator of Immune Response