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IL1A Protein (AA 113-271)

IL1A Origin: Human Host: Escherichia coli (E. coli) Recombinant ELISA, FACS
Catalog No. ABIN2667487
  • Target See all IL1A Proteins
    IL1A (Interleukin 1 alpha (IL1A))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 113-271
    Origin
    • 18
    • 12
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Source
    • 39
    • 13
    • 12
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Application
    ELISA, Flow Cytometry (FACS)
    Top Product
    Discover our top product IL1A Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.,Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Prior to use, reconstitute the lyophilized powder with 0.2 mLof PBS containing a carrier protein (e.g., 1 % BSA, protease free), pH 7.4. Re-cap vial, vortex. Allow the reconstituted standard to sit at room temperature for 15 minutes, vortex again to mix completely. The reconstituted standard stock solution can be aliquoted into polypropylene vials and stored at -70 °C for up to one month.
    Buffer
    Lyophilized in sterile-filtered PBS, pH 7.2, containing 1 % BSA.
    Handling Advice
    Use a manual defrost freezer and avoid repeated freeze thaw cycles.
    Storage
    4 °C
    Storage Comment
    Upon receipt, store unopened vials between 2°C and 8°C immediately and use within 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    IL1A (Interleukin 1 alpha (IL1A))
    Alternative Name
    IL-1alpha (IL1A Products)
    Synonyms
    IL-1A Protein, IL1 Protein, IL1-ALPHA Protein, IL1F1 Protein, IL-6 Protein, Il-1a Protein, IL-1 alpha Protein, IL-1alpha Protein, L1A Protein, interleukin 1 alpha Protein, interleukin 6 Protein, IL1A Protein, IL6 Protein, Il1a Protein
    Background
    IL-1 was isolated from human blood that had been exposed to a pathogenic bacterium. IL-1 is a pyrogen, and it is an activating factor for lymphocytes. It also damaged joints and influenced liver proteins (2). IL-1α binds to the cell surface type I and II IL-1 receptors (IL-1RI and IL-1RII). IL-1 and -β and IL-1RA can compete for binding to these receptors. However, only IL-1RI, not IL-1RII, is functional because IL-1RII lacks a cytoplasmic domain and is thus unable to transmit signals to downstream steps (3). IL-1α is expressed by cancer cells and promotes angiogenesis and metastasis of pancreatic cancer and human gastric cancer cell lines (4). In addition, IL-1 induced the expression of VEGF in colon cancer (5).
    Pathways
    NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints
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