PARP1 antibody (N-Term)

Catalog No. ABIN2668274

Product Details anti-PARP1 Antibody

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP1 antibody is un-conjugated

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Purification: None

Immunogen: This PARP-1 N-terminal antibody was raised against a His-tagged fusion protein corresponding to the N-terminal half of human PARP-1 was used to generate this PARP-1 antibody.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice:

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Storage: -20 °C

Storage Comment: Antibodies in solution can be stored at -20 °C for 2 years.

Expiry Date: 6 months

References for anti-PARP1 antibody (ABIN2668274)

Myers, Peddada, Chatterjee, Friedrich, Tomoda, Krings, Thomas, Maynard, Broeker, Thomson, Pollard, Yamanaka, Burlingame, Panning: "SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells." in: eLife, Vol. 5, pp. e10647, (2016) (PubMed).

Watanabe, Papoutsoglou, Maturi, Tsubakihara, Hottiger, Heldin, Moustakas: "Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation." in: The Journal of biological chemistry, Vol. 291, Issue 24, pp. 12706-23, (2016) (PubMed).

Matveeva, Maiorano, Zhang, Eteleeb, Convertini, Chen, Infantino, Stamm, Wang, Rouchka, Fondufe-Mittendorf: "Involvement of PARP1 in the regulation of alternative splicing." in: Cell discovery, Vol. 2, pp. 15046, (2016) (PubMed).

Krishnakumar, Gamble, Frizzell, Berrocal, Kininis, Kraus: "Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes." in: Science (New York, N.Y.), Vol. 319, Issue 5864, pp. 819-21, (2008) (PubMed).

Kim, Mauro, Gévry, Lis, Kraus: "NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1." in: Cell, Vol. 119, Issue 6, pp. 803-14, (2004) (PubMed).

Target Details for PARP1

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Alternative Name: PARP-1 (PARP1 Products)

Synonyms: ADPRT antibody, ADPRT 1 antibody, ADPRT1 antibody, ARTD1 antibody, PARP antibody, PARP-1 antibody, PPOL antibody, pADPRT-1 antibody, Adprt antibody, Parp-1 antibody, 5830444G22Rik antibody, AI893648 antibody, Adprp antibody, Adprt1 antibody, C80510 antibody, parp-1 antibody, sPARP-1 antibody, BEST:LD21673 antibody, CG17685 antibody, CG17696 antibody, CG17718 antibody, CG40411 antibody, D.PARP antibody, Dm.pARTa antibody, Dmel\\CG40411 antibody, LD21673.3prime antibody, PARP1 antibody, dPARP antibody, parp antibody, adprt1 antibody, padprt-1 antibody, ppol antibody, si:dkey-206f10.3 antibody, wu:fc60f12 antibody, zgc:110092 antibody, poly(ADP-ribose) polymerase 1 antibody, poly (ADP-ribose) polymerase 1 antibody, poly (ADP-ribose) polymerase family, member 1 antibody, Poly-(ADP-ribose) polymerase antibody, poly(ADP-ribose) polymerase 1 L homeolog antibody, PARP1 antibody, Parp1 antibody, Parp antibody, parp1.L antibody, parp1 antibody

Molecular Weight: 120 kDa

Gene ID: 142

Pathways: Apoptosis, Caspase Cascade in Apoptosis, DNA Damage Repair, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location