NFKBIA antibody (AA 32-291)

Catalog No. ABIN2668625

Product Details anti-NFKBIA Antibody

Target: NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))

Binding Specificity: AA 32-291

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This NFKBIA antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity Purified

Immunogen: This IkappaBalpha antibody was raised against a recombinant protein corresponding to amino acid residues 32-291 of human IkappaBalpha.

Clone: 6A920

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice:

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Storage: -80 °C

Storage Comment: Antibodies in solution can be stored at -80 °C for 2 years.

Expiry Date: 6 months

References for anti-NFKBIA antibody (ABIN2668625)

Blaabjerg, Christensen, Matsumoto, van der Meulen, Huising, Billestrup, Vale: "CRFR1 activation protects against cytokine-induced β-cell death." in: Journal of molecular endocrinology, Vol. 53, Issue 3, pp. 417-27, (2014) (PubMed).

Syeda, Grosjean, Houliston, Keogh, Carter, Paleolog, Wheeler-Jones: "Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappaB pathways." in: The Journal of biological chemistry, Vol. 281, Issue 17, pp. 11792-804, (2006) (PubMed).

Frobøse, Rønn, Heding, Mendoza, Cohen, Mandrup-Poulsen, Billestrup: "Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex." in: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 7, pp. 1587-96, (2006) (PubMed).

Jeong, Pise-Masison, Radonovich, Park, Brady: "A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity." in: The Journal of biological chemistry, Vol. 280, Issue 11, pp. 10326-32, (2005) (PubMed).

Larsen, Størling, Darville, Eizirik, Bonny, Billestrup, Mandrup-Poulsen: "Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells." in: Diabetologia, Vol. 48, Issue 12, pp. 2582-90, (2005) (PubMed).

Han, Karabiyikoglu, Kelly, Sobel, Yenari: "Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 23, Issue 5, pp. 589-98, (2003) (PubMed).

Target Details for NFKBIA

Target: NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))

Alternative Name: IkappaBalpha (NFKBIA Products)

Synonyms: IKBA antibody, MAD-3 antibody, NFKBI antibody, AI462015 antibody, Nfkbi antibody, RL/IF-1 antibody, ECI-6/IKBA antibody, NFKBIA antibody, ikbaB antibody, wu:fb81f08 antibody, zgc:56666 antibody, zgc:77616 antibody, ikbaA antibody, wu:fj16a07 antibody, zgc:85769 antibody, NFKB inhibitor alpha antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha antibody, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b antibody, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a antibody, NFKBIA antibody, Nfkbia antibody, nfkbiab antibody, nfkbiaa antibody

Molecular Weight: 40 kDa

Gene ID: 4792

Pathways: NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling