MLL/KMT2A antibody (AA 161-356)

Catalog No. ABIN2668648

Product Details anti-MLL/KMT2A Antibody

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Binding Specificity: AA 161-356

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This MLL/KMT2A antibody is un-conjugated

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP), Immunoprecipitation (IP)

Purification: Protein G Chromatography

Immunogen: This MLL1 antibody was raised against a recombinant protein corresponding to amino acids 161-356 of mouse MLL1.

Clone: N4-4

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice:

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Storage: -20 °C

Storage Comment: Antibodies in solution can be stored at -20 °C for 2 years.

Expiry Date: 6 months

References for anti-MLL/KMT2A antibody (ABIN2668648)

Aguilar-Arnal, Katada, Orozco-Solis, Sassone-Corsi: "NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1." in: Nature structural & molecular biology, Vol. 22, Issue 4, pp. 312-8, (2015) (PubMed).

Jin, Zhao, Yi, Nakata, Kalota, Gewirtz: "c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis." in: The Journal of clinical investigation, Vol. 120, Issue 2, pp. 593-606, (2010) (PubMed).

Target Details for MLL/KMT2A

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Alternative Name: MLL / HRX (MLL Products)

Molecular Weight: 440 kDa

Gene ID: 4297

Pathways: Warburg Effect