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Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) antibody

Antigen

Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD)
Synonyms PGDH, PGDH1, 15-PGDH, SDR36C1, MGC80546, MGC79454, MGC127443, HPGD, DKFZp469E0623, AV026552, MGC14001
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
4 references available
Catalog no. ABIN268223
Quantity 25 µl  (2.0 mg/ml)  (Variants)
Price Product not available in this region.
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Additional Information
Application Details Publications Alternatives Variants back to top

Alternative name HPGD
Gene ID 3248
Immunogen Purified type I human placental 15-PGDH protein.
Cross-Reactivity Human
Description 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a novel tumor suppressor in theCOX-2 pathway. The protein is found in many normal tissues and appears to bedown-regulated in colorectal and lung carcinoma tissue. Alternate Names: anti-15-hydroxyprostaglandin dehydrogenase [NAD+] antibody, anti-Prostaglandindehydrogenase 1 antibody, anti-HPGD antibody, anti-PGDH1 antibody.
Specificity This antibody is specific for 15-PGDH. Species Reactivity: This antibody reacts with human 15-PGDH protein. No other species have been tested. Localization: Cytoplasmic.

Application Details
Publications Alternatives Variants back to top

Application Notes Positive Controls: Treated A549 lung carcinoma cell lysates (see note) and LoVo colon carcinoma celllysates.
Concentration 2.0 mg/ml
Purification Purified
Buffer Tris-glycine, 150mM NaCl. Preservative: 0.05% sodium azide.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Giannoulias, Patel, Holloway et al.: "Differential changes in 15-hydroxyprostaglandin dehydrogenase and prostaglandin H synthase (types I and II) in human pregnant myometrium." in: The Journal of clinical endocrinology and metabolism, Vol. 87, Issue 3, pp. 1345-52, 2002 (PubMed).

Ding, Tong, Liu et al.: "NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer." in: Carcinogenesis, Vol. 26, Issue 1, pp. 65-72, 2004 (PubMed).

Backlund, Mann, Holla et al.: "Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer." in: Cancer research, Vol. 68, Issue 22, pp. 9331-7, 2008 (PubMed).

Hughes, Otani, Yang et al.: "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer." in: Cancer prevention research (Philadelphia, Pa.), Vol. 1, Issue 4, pp. 241-9, 2009 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD)", type "Antibodies"
Hosts Rabbit (34), Goat (6), Mouse (6)
Reactivities Human (45), Mouse (Murine) (22), Rat (Rattus) (22), Cow (Bovine) (19), Horse (Equine) (18), Pig (Porcine) (18), Cat (Feline) (1), Chicken (1), Dog (Canine) (1), Monkey (1)
Applications Western Blotting (WB) (29), Immunofluorescence (IF) (19), ELISA (16), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (10), Immunohistochemistry (IHC) (9), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Flow Cytometry (FACS) (2), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Biotin (2), HRP (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes C-Term (2), N-Term (2), AA 1-266 (1)