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Details for Product No. ABIN268223

Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) antibody

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Antigen
Synonyms 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1, AV026552, MGC80546, MGC79454
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 4 references available
Catalog no. ABIN268223
Quantity 25 µL
Price
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Immunogen Purified type I human placental 15-PGDH protein.
Specificity This antibody is specific for 15-PGDH. Species Reactivity: This antibody reacts with human 15-PGDH protein. No other species have been tested. Localization: Cytoplasmic.
Cross-Reactivity Human
Purification Purified
Alternative Name HPGD
Background 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a novel tumor suppressor in theCOX-2 pathway. The protein is found in many normal tissues and appears to bedown-regulated in colorectal and lung carcinoma tissue. Alternate Names: anti-15-hydroxyprostaglandin dehydrogenase [NAD+] antibody, anti-Prostaglandindehydrogenase 1 antibody, anti-HPGD antibody, anti-PGDH1 antibody.
Gene ID 3248
Application Notes Positive Controls: Treated A549 lung carcinoma cell lysates (see note) and LoVo colon carcinoma celllysates.
Restrictions For Research Use only
Format Liquid
Concentration 2.0 mg/ml
Buffer Tris-glycine, 150mM NaCl. Preservative: 0.05% sodium azide.
Preservative Sodium azide
Storage 4 °C
Giannoulias, Patel, Holloway et al.: "Differential changes in 15-hydroxyprostaglandin dehydrogenase and prostaglandin H synthase (types I and II) in human pregnant myometrium." in: The Journal of clinical endocrinology and metabolism, Vol. 87, Issue 3, pp. 1345-52, 2002 (PubMed).

Ding, Tong, Liu et al.: "NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer." in: Carcinogenesis, Vol. 26, Issue 1, pp. 65-72, 2004 (PubMed).

Backlund, Mann, Holla et al.: "Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer." in: Cancer research, Vol. 68, Issue 22, pp. 9331-7, 2008 (PubMed).

Hughes, Otani, Yang et al.: "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer." in: Cancer prevention research (Philadelphia, Pa.), Vol. 1, Issue 4, pp. 241-9, 2009 (PubMed).

Alternatives for antigen "Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD)", type "Antibodies"
Hosts (43), (21), (9)
Reactivities (71), (17), (15), (13), (12), (2), (1), (1)
Applications (53), (28), (23), (13), (10), (9), (8), (4), (3), (3), (1), (1)
Conjugates (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (6), (2), (2), (1), (1), (1)
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