Dicer 1, Ribonuclease Type III (DICER1) antibody

Details for Product No. ABIN268305
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Antigen
Synonyms DCR1, Dicer, HERNA, MNG1, D12Ertd7e, mKIAA0928, 1110006F08Rik, fc39d11, fc74b05, wu:fc39d11, wu:fc74b05, dcr1, dicer, herna, DICER1, dicer1
Reactivity
Human, Mouse (Murine)
(50), (28), (20), (13), (13), (2), (1), (1), (1)
Host
Rabbit
(45), (9), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(31), (28), (11), (10), (7), (5), (3), (2), (2), (2), (1)
Pubmed 3 references available
Catalog no. ABIN268305
Quantity 0.1 mg
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Immunogen Rabbit anti-mouse Dicer polyclonal antibody was raised against a peptide correspondingto amino acids 132-150 and 1017-1033 of mouse Dicer. These sequences are over 90%homologous in human and rat, but testing shows no response in human and rat ovary atthe recommended testing conditions.
Isotype IgG
Specificity In mouse ovary, a 217 kDa band is observed. Species Reactivity: Cross-reacts with Mouse. Expected to cross-react with Human and Rat due to over 90%sequence homology with immunogen, but testing shows no response in human and ratovary at the recommended testing conditions. Not yet tested in other species.
Cross-Reactivity Mouse (Murine)
Purification Purified
Alternative Name DICER1
Background Dicer is an RNaseIII-like enzyme which cleaves double-stranded RNA into 21-23 ntRNAs. These RNAs are referred to as siRNA (short interfering RNA). It is believed to beessential in siRNA-mediated gene suppression.
Application Notes Positive Controls: mouse ovary
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. Preservative: 0.05% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
General Zhang, Kolb, Brondani et al.: "Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP." in: The EMBO journal, Vol. 21, Issue 21, pp. 5875-85, 2002 (PubMed).

Provost, Silverstein, Dishart et al.: "Dicer is required for chromosome segregation and gene silencing in fission yeast cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16648-53, 2002 (PubMed).

Doi, Zenno, Ueda et al.: "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors." in: Current biology : CB, Vol. 13, Issue 1, pp. 41-6, 2003 (PubMed).

Hosts (45), (9), (3)
Reactivities (50), (28), (20), (13), (13), (2), (1), (1), (1)
Applications (31), (28), (11), (10), (7), (5), (3), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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