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Dicer 1, Ribonuclease Type III (DICER1) antibody

Details for Product No. ABIN268305, Supplier: Log in to see
Antigen
  • dcr1
  • dicer
  • herna
  • DICER1
  • dicer1
  • 1110006F08Rik
  • D12Ertd7e
  • mKIAA0928
  • DCR1
  • Dicer
  • HERNA
  • MNG1
  • DICER
  • fc39d11
  • fc74b05
  • wu:fc39d11
  • wu:fc74b05
  • dicer 1, ribonuclease type III
  • endoribonuclease Dicer
  • double-stranded RNA-specific endoribonuclease type III
  • Dicer1, Dcr-1 homolog (Drosophila)
  • DICER1
  • CpipJ_CPIJ010534
  • dicer1
  • Dicer1
Alternatives
anti-Mouse (Murine) Dicer 1, Ribonuclease Type III antibody for Western Blotting
Reactivity
Human, Mouse (Murine)
153
109
65
2
1
1
1
1
1
1
1
1
Host
Rabbit
92
63
5
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
117
56
40
36
26
25
14
13
9
6
1
1
1
1
Options
Supplier
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Available images

Immunogen Rabbit anti-mouse Dicer polyclonal antibody was raised against a peptide corresponding to amino acids 132-150 and 1017-1033 of mouse Dicer (EDL18787).
Specificity In mouse ovary, a 217 kDa band is observed.
Purification Protein G purified
Alternative Name Dicer (DICER1 Antibody Abstract)
Background Gene Symbol: DICER1
Molecular Weight Theoretical MW: 218.7 kDa
Gene ID 23405
UniProt Q8R418
Research Area DNA/RNA, Chromatin and Nuclear Signaling
Pathways Regulatory RNA Pathways, Stem Cell Maintenance, Ribonucleoprotein Complex Subunit Organization
Application Notes Western Blot 0.5-3 μg/mL, Immunohistochemistry 1:20-1:1000, Immunohistochemistry-Paraffin 1:20-1:1000WB: Use at a dilution of 1/500 - 1/1000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS
Buffer contains: 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Dicer 1, Ribonuclease Type III (DICER1) antibody (ABIN268305) Western Blot: Dicer Antibody [ABIN268305] - Mouse ovary tissue lysate probed with Dic...
Product cited in: Lu, Zhou, Zhang, Ji, Li, Shi, Bu: "Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation." in: World journal of gastroenterology, Vol. 21, Issue 21, pp. 6591-603, 2015 (PubMed). (Sample species: Mouse (Murine)). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Chiappinelli, Haynes, Brent, Goodfellow: "Reduced DICER1 elicits an interferon response in endometrial cancer cells." in: Molecular cancer research : MCR, Vol. 10, Issue 3, pp. 316-25, 2012 (PubMed). (Sample species: Human). Further details: Western Blotting

Grelier, Voirin, Ay, Cox, Chabaud, Treilleux, Léon-Goddard, Rimokh, Mikaelian, Venoux, Puisieux, Lasset, Moyret-Lalle: "Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype." in: British journal of cancer, Vol. 101, Issue 4, pp. 673-83, 2009 (PubMed). Further details: Western Blotting,Immunohistochemistry (Paraffin-embedded Sections)

Poleshko, Palagin, Zhang, Boimel, Castagna, Adams, Skalka, Katz: "Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response." in: Journal of virology, Vol. 82, Issue 5, pp. 2313-23, 2008 (PubMed). Further details: Western Blotting

Chen, Murchison, Tang, Callis, Tatsuguchi, Deng, Rojas, Hammond, Schneider, Selzman, Meissner, Patterson, Hannon, Wang: "Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 6, pp. 2111-6, 2008 (PubMed).

Barbato, Ciotti, Serafino, Calissano, Cogoni: "Dicer expression and localization in post-mitotic neurons." in: Brain research, Vol. 1175, pp. 17-27, 2007 (PubMed). (Sample species: Rat (Rattus)). Further details: Western Blotting

Grivna, Pyhtila, Lin: "MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 36, pp. 13415-20, 2006 (PubMed).

Lugli, Larson, Martone, Jones, Smalheiser: "Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner." in: Journal of neurochemistry, Vol. 94, Issue 4, pp. 896-905, 2005 (PubMed). Further details: Western Blotting

Doi, Zenno, Ueda, Ohki-Hamazaki, Ui-Tei, Saigo: "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors." in: Current biology : CB, Vol. 13, Issue 1, pp. 41-6, 2003 (PubMed).

Zhang, Kolb, Brondani, Billy, Filipowicz: "Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP." in: The EMBO journal, Vol. 21, Issue 21, pp. 5875-85, 2002 (PubMed).

Provost, Silverstein, Dishart, Walfridsson, Djupedal, Kniola, Wright, Samuelsson, Radmark, Ekwall: "Dicer is required for chromosome segregation and gene silencing in fission yeast cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16648-53, 2002 (PubMed).