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tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) (AA 39-53) antibody

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AA 39-53
(16), (14), (13), (8), (7), (7), (7), (7), (4), (3), (2), (2), (1), (1), (1), (1)
Human, Mouse (Murine)
(81), (48), (21), (1), (1), (1), (1), (1)
(80), (15)
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(66), (41), (32), (12), (11), (10), (4), (2), (1)
Pubmed 2 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen This antibody was raised against synthetic peptides corresponding amino acids 39-53 and 361-376 of mouse Dnmt2.
Isotype IgG
Cross-Reactivity (Details) Not yet tested in other species.
Purification Protein G purified
Alternative Name DNMT2 / TRDMT1 (TRDMT1 Antibody Abstract)
Background Methylation of DNA at cytosine residues plays an important role in regulation of geneexpression, genomic imprinting and is essential for mammalian development.Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulkgenomic DNA may be linked with development of cancer. To date, 3 families ofmammalian DNA methyltransferase genes have been identified which include Dnmt1,Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells andinactivation of this gene causes global demethylation of genomic DNA and embryoniclethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does notaffect DNA methylation or maintenance of methylation. Dnmt2 contains all the sequencemotifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the largeN-terminal regulatory domain common to other eukaryotic methyltransferases. Alternate Names: anti-DNA methyltransferase 2 antibody.
Gene Symbol: TRDMT1
Gene ID 1787, 13434
Application Notes Western Blot: Detects a band of approximately 42 kDa.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 0.05 % BSA, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Product cited in: Kawasaki, Taira: "Induction of DNA methylation and gene silencing by short interfering RNAs in human cells." in: Nature, Vol. 431, Issue 7005, pp. 211-7, 2004 (PubMed).

Background publications Okano, Xie, Li: "Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells." in: Nucleic acids research, Vol. 26, Issue 11, pp. 2536-40, 1998 (PubMed).

Catalog No. ABIN268327

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