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Details for Product No. ABIN268327

tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) antibody

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Antigen
Synonyms Dnmt2, Rnmt2, DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1, dnmt2, DNMT3L, MGC89267
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN268327
Quantity 0.1 mg
Price
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Immunogen This antibody was raised against synthetic peptides corresponding amino acids 39-53and 361-376 of mouse Dnmt2.
Isotype IgG
Specificity Species Reactivity: Cross-reacts with Human and Mouse. Not yet tested in other species. Localization: Nuclear.
Cross-Reactivity Human, Mouse (Murine)
Alternative Name DNMT2 / TRDMT1
Background Methylation of DNA at cytosine residues plays an important role in regulation of geneexpression, genomic imprinting and is essential for mammalian development.Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulkgenomic DNA may be linked with development of cancer. To date, 3 families ofmammalian DNA methyltransferase genes have been identified which include Dnmt1,Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells andinactivation of this gene causes global demethylation of genomic DNA and embryoniclethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does notaffect DNA methylation or maintenance of methylation. Dnmt2 contains all the sequencemotifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the largeN-terminal regulatory domain common to other eukaryotic methyltransferases. Alternate Names: anti-DNA methyltransferase 2 antibody.
Gene ID 1787, 13434
Application Notes Suggested working dilutions: Western Blot 2 ug/ml. Positive Controls: mouse testis
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS. Preservative: Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Okano, Xie, Li: "Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells." in: Nucleic acids research, Vol. 26, Issue 11, pp. 2536-40, 1998 (PubMed).

Kawasaki, Taira: "Induction of DNA methylation and gene silencing by short interfering RNAs in human cells." in: Nature, Vol. 431, Issue 7005, pp. 211-7, 2004 (PubMed).

Alternatives for antigen "tRNA Aspartic Acid Methyltransferase 1 (TRDMT1)", type "Antibodies"
Hosts (43), (12)
Reactivities (46), (38), (13), (13), (13), (1), (1), (1)
Applications (44), (16), (14), (10), (7), (4), (3), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (5), (3), (2), (2), (1), (1), (1), (1), (1)
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