Tachykinin Receptor 3 (TACR3) antibody

Antigen: Tachykinin Receptor 3 (TACR3)

Synonyms: NK3R, TAC3RL, MGC148060, MGC148061, TACR3, Tacr3

Clonality: Polyclonal

Host: Rabbit

Reactivity: Guinea Pig

Conjugate: Un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Catalog no.: ABIN268379

Additional Information

Gene ID: 6870

Immunogen: ABIN152452 was raised against a synthetic peptide at the c-terminus of rat NK-3conjugated to bovine thyroglobulin.

Cross-Reactivity: Guinea Pig, Mouse (Murine), Rat (Rattus)

Format: Serum

Description: The tachykinins belong to an evolutionary conserved family of peptide neurotransmittersthat share the c-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an establishedrole in neurotransmission. The mammalian tachykinins include substance P, neurokininA (NKA) and neurokinin B (NKB) which exert their effects by binding to specificreceptors. Tachykinin peptides are important in the mediation of many physiologicaland pathological processes including inflammation, pain, migraine headache and allergyinduced asthma.Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 whichhave preferential affinities for SP, NKA and NKB respectively. All three receptors sharea high degree of sequence homology, have seven transmembrane spanning domainsand similar signal transduction mechanisms (e.g. G-protein coupled activation ofphospholipase C). Alternate Names: anti-Neurokinin B receptor antibody, anti-Neuromedin K Receptor antibody, anti-NK3receptor antibody, anti-NK3R antibody, anti-TAC3R antibody, anti-TAC3RL antibody,anti-Tachykinin receptor 3 antibody, anti-TACR3 antibody.

Specificity: ABIN152452 is specific to the NK-3 receptor. Specificity was verified by the localizationof immunohistochemical staining as well as pre-absorption studies with NK-3 peptide.(1). Species Reactivity: ABIN152452 can be used for detection of NK-3 receptor in rat, mouse and guinea pig inbrain, spinal cord and ileum. (1) Customer feedback suggests that human reactivity isnegative. Localization: In immunohistochemical experiments staining of the neuronal cell bodies and fibers isseen and staining is believed to be localized to the plasma membrane.

Application Details

Application Notes: This antibody may be used for immunohistochemistry on frozen sections.

Purification: Serum

Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Research Area: Receptors, Neurotransmitters

Restrictions: For Research Use only

Publications

Tooney, Au, Chahl: "Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex." in: Neuroscience letters, Vol. 283, Issue 3, pp. 185-8, 2000 (PubMed).

Yip, Chahl: "Localization of NK1 and NK3 receptors in guinea-pig brain." in: Regulatory peptides, Vol. 98, Issue 1-2, pp. 55-62, 2001 (PubMed).

Dick, tom Dieck, Altrock et al.: "The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina." in: Neuron, Vol. 37, Issue 5, pp. 775-86, 2003 (PubMed).

Feigenspan, Janssen-Bienhold, Hormuzdi et al.: "Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 13, pp. 3325-34, 2004 (PubMed).

Howe, Somponpun, Sladek: "Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 45, pp. 10103-10, 2004 (PubMed).

Haley, Flynn: "Agonist and hypertonic saline-induced trafficking of the NK3-receptors on vasopressin neurons within the paraventricular nucleus of the hypothalamus." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 290, Issue 5, pp. R1242-50, 2006 (PubMed).

Beltran, Hammond, Acland et al.: "A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa." in: Investigative ophthalmology & visual science, Vol. 47, Issue 4, pp. 1669-81, 2006 (PubMed).

Broccardo, Linari, Agostini et al.: "Expression of NK-1 and NK-3 tachykinin receptors in pancreatic acinar cells after acute experimental pancreatitis in rats." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 291, Issue 3, pp. G518-24, 2006 (PubMed).

Oh, Khan, Novelli et al.: "Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1679-84, 2007 (PubMed).