Tachykinin Receptor 1 (TACR1) antibody

Antigen: Tachykinin Receptor 1 (TACR1)

Synonyms: SPR, NK1R, NKIR, TAC1R, TACR1

Clonality: Monoclonal (Substance P Recptor)

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)

Catalog no.: ABIN268406

Additional Information

Gene ID: 6869

Immunogen: A peptide derived from the human NK-1 amino acids with a cysteine added forconjugation to KLH.

Cross-Reactivity: Human, Rat (Rattus)

Clone: Substance P Recptor

Description: The tachykinins belong to an evolutionary conserved family of peptide neurotransmittersthat share the c-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an establishedrole in neurotransmission. The mammalian tachykinins include substance P, neurokininA (NKA) and neurokinin B (NKB) which exert their effects by binding to specificreceptors. Tachykinin peptides are important in the mediation of many physiologicaland pathological processes including inflammation, pain, migraine headache and allergyinduced asthma. Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 whichhave preferential affinities for SP, NKA and NKB respectively. All three receptors sharea high degree of sequence homology, have seven transmembrane spanning domainsand similar signal transduction mechanisms (e.g. G-protein coupled activation ofphospholipase C). Alternate Names: anti-NK1 receptor antibody, anti-NK1R antibody, anti-SPR antibody, anti-Substance Preceptor antibody, anti-TAC1R antibody, anti-Tachykinin receptor 1 antibody,anti-TACR1 antibody, anti-NK-1r antibody.

Specificity: This antibody is specific for human NK-1. Species Reactivity: Human, rat.

Application Details

Application Notes: Immunohistochemistry 10 ug/ml,Positive Controls: SF9 whole cell membrane extracts

Purification: Aff - Purified

Buffer: PBS. Preservative: 0.05% sodium azide.

Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Research Area: Hormones, Receptors

Restrictions: For Research Use only

Publications

Vigna, Bowden, McDonald et al.: "Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 14, Issue 2, pp. 834-45, 1994 (PubMed).

Mantyh, Allen, Ghilardi et al.: "Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 7, pp. 2622-6, 1995 (PubMed).

Mantyh, DeMaster, Malhotra et al.: "Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation." in: Science (New York, N.Y.), Vol. 268, Issue 5217, pp. 1629-32, 1995 (PubMed).

Mantyh, Rogers, Ghilardi et al.: "Differential expression of two isoforms of the neurokinin-1 (substance P) receptor in vivo." in: Brain research, Vol. 719, Issue 1-2, pp. 8-13, 1997 (PubMed).

Mantyh, Pappas, Lapp et al.: "Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum." in: Gastroenterology, Vol. 111, Issue 5, pp. 1272-80, 1996 (PubMed).

Mantyh, Rogers, Honore et al.: "Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor." in: Science (New York, N.Y.), Vol. 278, Issue 5336, pp. 275-9, 1997 (PubMed).

Tooney, Au, Chahl: "Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex." in: Neuroscience letters, Vol. 283, Issue 3, pp. 185-8, 2000 (PubMed).

Tooney, Crawter, Chahl: "Increased tachykinin NK(1) receptor immunoreactivity in the prefrontal cortex in schizophrenia." in: Biological psychiatry, Vol. 49, Issue 6, pp. 523-7, 2001 (PubMed).

Benarroch, Schmeichel, Low et al.: "Depletion of ventromedullary NK-1 receptor-immunoreactive neurons in multiple system atrophy." in: Brain : a journal of neurology, Vol. 126, Issue Pt 10, pp. 2183-90, 2003 (PubMed).

Lai, Ho, Kilpatrick et al.: "Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 20, pp. 7771-6, 2006 (PubMed).

Borghese, Werner, Topf et al.: "An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice." in: The Journal of pharmacology and experimental therapeutics, Vol. 319, Issue 1, pp. 208-18, 2006 (PubMed).

Fong, Potts: "Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea." in: The Journal of physiology, Vol. 575, Issue Pt 3, pp. 869-85, 2006 (PubMed).

Hazlett, McClellan, Barrett et al.: "Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection." in: Investigative ophthalmology & visual science, Vol. 48, Issue 2, pp. 797-807, 2007 (PubMed).

Schmidtko, Gao, Koenig et al.: "cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 34, pp. 8568-76, 2008 (PubMed).

Nayate, Moore, Weiss et al.: "Cardiac damage after lesions of the nucleus tractus solitarii." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 296, Issue 2, pp. R272-9, 2009 (PubMed).