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Details for Product No. ABIN268414

Bestrophin 1 (BEST1) antibody

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Antigen
Synonyms ARB, BEST, BMD, RP50, TU15B, VMD2, Bmd, Vmd2, mBest1, CG6264, Dbest, Dmel\\CG6264, anon-WO0118547.380, best, dBest1, dbest1, dmBest1, BEST1, best-1
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunofluorescence (IF), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN268414
Quantity 25 µL
Price
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Immunogen Synthetic peptide conjugated to KLH [KDHMDPYWALENRDEAHS].
Isotype IgG1
Specificity Species Reactivity: ABIN152509 recognizes human, porcine, and monkey. This antibody does not work inrat. Other species have not been tested.
Cross-Reactivity Human, Monkey
Purification Ascites
Alternative Name Bestrophin-1
Background Best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an autosomalform of macular degeneration, characterized by a depressed light peak in theelectrooculogram (EOG). It is inherited and has an early onset. Bestrophin is a 68 kDabasolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin'sfunction is still unknown, but data suggests that it is a chloride channel that plays a rolein generating the altered EOG in Best disease patients. In addition, Bestrophin is auseful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells.
Gene ID 7439
Application Notes Western Blot 1:1,000. Positive Controls: Pig RPE (Retinal Pigment Epithelium) whole cell extract
Restrictions For Research Use only
Format Liquid
Buffer Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage -20 °C
Caldwell, Kakuk, Griesinger et al.: "Bestrophin gene mutations in patients with Best vitelliform macular dystrophy." in: Genomics, Vol. 58, Issue 1, pp. 98-101, 1999 (PubMed).

Marmorstein, Marmorstein, Rayborn et al.: "Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 23, pp. 12758-63, 2000 (PubMed).

Klimanskaya, Hipp, Rezai et al.: "Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics." in: Cloning and stem cells, Vol. 6, Issue 3, pp. 217-45, 2005 (PubMed).

Alternatives for antigen "Bestrophin 1 (BEST1)", type "Antibodies"
Hosts (17), (9)
Reactivities (16), (4), (3), (3), (1)
Applications (17), (8), (5), (5), (5), (2), (1), (1), (1)
Conjugates (3), (3)
Epitopes (4), (4), (3), (2), (1), (1), (1), (1)
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