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Huntingtin Interacting Protein 1 (HIP1) antibody
Alternatives Western Blotting (WB)
|3 references available|
|Price||Product not available in this region.|
|Immunogen||Human 3'-HIP1 (~65 kDa).|
|Description||Huntingtin disease, a neurodegenerate disease, is caused by the expansion of apolymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) isa reportedly proapoptotic, cargo-specific adaptor protein that may be involved in thepathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it islikely to be involved in the recruitment of clathrin coats to lipid membranes and it mayalso factor in tumorigenesis by allowing the survival of precancerous and cancerouscells. Since HIP-1 expression is significantly associated with prostate and colon cancermetastasis, HIP-1 can serve as a putative prognostic factor for prostate and coloncancers. Alternate Names: anti-HIP I antibody, anti-Huntingtin interacting protein 1 antibody.|
|Specificity||ABIN152544 is specific for human HIP1.Localization:. Species Reactivity: ABIN152544 recognizes human HIP1 proteins. It does not appear to work in rat. Otherspecies have not been tested. Localization: Cytoplasmic.|
|Synonyms||ILWEQ, MGC126506, CG10971, DmelCG10971, KIAA4113, MGC27616, mKIAA4113, 2610109B09Rik, A930014B11Rik, E130315I21Rik, HYPB, SET2, HIF-1, KMT3A, HBP231, HSPC069, p231HBP, FLJ16420, FLJ22472, FLJ23184, FLJ45883, FLJ46217, KIAA1732, hip1, MGC78813, HIP1|
|Application Notes||Suggested working dilutions: Western Blot 1:10,000|
|Storage||Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.|
|Restrictions||For Research Use only|
Rao, Chang, Kumar et al.: "Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors." in: Molecular and cellular biology, Vol. 21, Issue 22, pp. 7796-806, 2001 (PubMed).
Rao, Hyun, Kumar et al.: "Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival." in: The Journal of clinical investigation, Vol. 110, Issue 3, pp. 351-60, 2002 (PubMed).
Hyun, Rao, Saint-Dic et al.: "HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains." in: The Journal of biological chemistry, Vol. 279, Issue 14, pp. 14294-306, 2004 (PubMed).
|Hosts||Rabbit (24), Mouse (13)|
|Reactivities||Human (37), Rat (Rattus) (22), Mouse (Murine) (21), Chicken (19), Dog (Canine) (19), Horse (Equine) (18), Rabbit (18), Cat (Feline) (1), Cow (Bovine) (1)|
|Applications||Western Blotting (WB) (22), Immunofluorescence (IF) (16), ELISA (12), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (IHC) (3), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)|
|Epitopes||C-Term (3), Center (1)|