Huntingtin Interacting Protein 1 (HIP1) antibody

Antigen: Huntingtin Interacting Protein 1 (HIP1)

Synonyms: ILWEQ, MGC126506, CG10971, DmelCG10971, KIAA4113, MGC27616, mKIAA4113, 2610109B09Rik, A930014B11Rik, E130315I21Rik, HYPB, SET2, HIF-1, KMT3A, HBP231, HSPC069, p231HBP, FLJ16420, FLJ22472, FLJ23184, FLJ45883, FLJ46217, KIAA1732, hip1, MGC78813, HIP1

Clonality: Monoclonal (1B11)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN268423

Additional Information

Alternative name: HIP1

Gene ID: 3092

Immunogen: Human 3'-HIP1 (~65 kDa).

Cross-Reactivity: Human

Format: Ascites

Isotype: IgG1

Clone: 1B11

Description: Huntingtin disease, a neurodegenerate disease, is caused by the expansion of apolymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) isa reportedly proapoptotic, cargo-specific adaptor protein that may be involved in thepathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it islikely to be involved in the recruitment of clathrin coats to lipid membranes and it mayalso factor in tumorigenesis by allowing the survival of precancerous and cancerouscells. Since HIP-1 expression is significantly associated with prostate and colon cancermetastasis, HIP-1 can serve as a putative prognostic factor for prostate and coloncancers. Alternate Names: anti-HIP I antibody, anti-Huntingtin interacting protein 1 antibody.

Specificity: ABIN152545 is specific for human HIP1. Does not cross-react with HIP1r.Localization:. Species Reactivity: ABIN152545 recognizes human. It does not appear to work in rat. Other species havenot been tested. Localization: Cytoplasmic.

Synonyms: ILWEQ, MGC126506, CG10971, DmelCG10971, KIAA4113, MGC27616, mKIAA4113, 2610109B09Rik, A930014B11Rik, E130315I21Rik, HYPB, SET2, HIF-1, KMT3A, HBP231, HSPC069, p231HBP, FLJ16420, FLJ22472, FLJ23184, FLJ45883, FLJ46217, KIAA1732, hip1, MGC78813, HIP1

Application Details

Application Notes: By Western blot, this antibody recognizes a band at ~115 kDa, representing HIP1 protein. Suggested working dilutions: *Western Blot - 1:10,000 (ECL)Immunofluorescence - NDImmunohistochemistry - NDImmunoprecipitation - ND

Purification: Ascites

Buffer: Preservative: Sodium Azide.

Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Restrictions: For Research Use only

Publications

Rao, Chang, Kumar et al.: "Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors." in: Molecular and cellular biology, Vol. 21, Issue 22, pp. 7796-806, 2001 (PubMed).

Rao, Hyun, Kumar et al.: "Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival." in: The Journal of clinical investigation, Vol. 110, Issue 3, pp. 351-60, 2002 (PubMed).