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Details for Product No. ABIN268423

Huntingtin Interacting Protein 1 (HIP1) antibody

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Antigen
Synonyms HIP-I, ILWEQ, 2610109B09Rik, A930014B11Rik, E130315I21Rik, mKIAA4113, CG10971, Dmel\\CG10971, Hip1R, hip1, MGC78813
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN268423
Quantity 25 µL
Price
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Immunogen Human 3'-HIP1 (~65 kDa).
Clone 1B11
Isotype IgG1
Specificity ABIN152545 is specific for human HIP1. Does not cross-react with HIP1r.Localization:. Species Reactivity: ABIN152545 recognizes human. It does not appear to work in rat. Other species havenot been tested. Localization: Cytoplasmic.
Cross-Reactivity Human
Purification Ascites
Alternative Name HIP1
Background Huntingtin disease, a neurodegenerate disease, is caused by the expansion of apolymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) isa reportedly proapoptotic, cargo-specific adaptor protein that may be involved in thepathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it islikely to be involved in the recruitment of clathrin coats to lipid membranes and it mayalso factor in tumorigenesis by allowing the survival of precancerous and cancerouscells. Since HIP-1 expression is significantly associated with prostate and colon cancermetastasis, HIP-1 can serve as a putative prognostic factor for prostate and coloncancers. Alternate Names: anti-HIP I antibody, anti-Huntingtin interacting protein 1 antibody.
Gene ID 3092
Application Notes By Western blot, this antibody recognizes a band at ~115 kDa, representing HIP1 protein. Suggested working dilutions: *Western Blot - 1:10,000 (ECL)Immunofluorescence - NDImmunohistochemistry - NDImmunoprecipitation - ND
Restrictions For Research Use only
Format Liquid
Buffer Preservative: Sodium Azide.
Preservative Sodium azide
Storage -20 °C
Rao, Chang, Kumar et al.: "Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors." in: Molecular and cellular biology, Vol. 21, Issue 22, pp. 7796-806, 2001 (PubMed).

Rao, Hyun, Kumar et al.: "Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival." in: The Journal of clinical investigation, Vol. 110, Issue 3, pp. 351-60, 2002 (PubMed).

Alternatives for antigen "Huntingtin Interacting Protein 1 (HIP1)", type "Antibodies"
Hosts (31), (17)
Reactivities (46), (16), (15), (12), (12)
Applications (39), (15), (11), (10), (4), (3), (3), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (3), (1)
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