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Leucine-Rich Repeat Kinase 2 (LRRK2) (C-Term) antibody

Details for Product No. ABIN268762
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Antigen
Synonyms LRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2, 4921513O20Rik, 9330188B09Rik, AW561911, D630001M17Rik, Gm927, cI-46
Epitope
C-Term
(45), (38), (36), (19), (12), (12), (8), (6), (6), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(173), (72), (69), (33), (13), (13), (2)
Host
Goat
(99), (80), (6), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (10), (8), (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB), Immunoelectron Microscopy (IEM), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA
(161), (68), (43), (42), (33), (20), (16), (12), (12), (6), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN268762
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Immunogen Synthetic peptide CELAEKMRRTSV, representing the near the C- Terminus of the human protein sequence according to NP_940980.
Isotype IgG
Cross-Reactivity (Details) Expected cross-reactivity based on sequence identity: Cow
Purification affinity purified
Alternative Name PARK8 / LRRK2
Background This gene is a member of the leucine-rich repeat kinase family and encodes a proteinwith an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, aDFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40domain. The protein is present largely in the cytoplasm but also associates with themitochondrial outer membrane. Mutations in this gene have been associated withParkinson disease-8. Alternate Names: anti-LRRK2 antibody, anti-PARK8 antibody, anti-ROCO2 antibody, anti-FLJ45829antibody, anti-DKFZp434H2111 antibody, anti-leucine-rich repeat kinase 2 antibody,anti-dardarin antibody, anti-Parkinson disease (autosomal dominant) 8 antibody.
Gene Symbol: LRRK2
Gene ID 120892
NCBI Accession NP_940980
Application Notes This antibody is useful for Electron Microscopy (PMID:19640926) and Immunocytochemistry as reported in the literature. (PMID 21696411). In paraffin embedded Human Brain (hippocampus) shows staining of neuronal cytoplasm.
Recommended dilutions: Electron Microscopy 1:10-1:500, Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Paraffin 1-2 µg/mL, Peptide ELISA Detection limit 1:64000, Western Blot 0.3-1 µg/mL
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris-saline [pH 7.3] with 0.5 % BSA, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
General Paisán-Ruíz, Jain, Evans et al.: "Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease." in: Neuron, Vol. 44, Issue 4, pp. 595-600, 2004 (PubMed).

Alegre-Abarrategui, Ansorge, Esiri et al.: "LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease." in: Neuropathology and applied neurobiology, Vol. 34, Issue 3, pp. 272-83, 2008 (PubMed).

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