Add to Basket
Order hotline:
+1 404 474 4654
+1 888 205 9894 (TF)

Leucine-Rich Repeat Kinase 2 (LRRK2) antibody

Antigen

Leucine-Rich Repeat Kinase 2 (LRRK2)
Synonyms Gm927, cI-46, AW561911, 4921513O20Rik, 9330188B09Rik, D630001M17Rik, PARK8, RIPK7, ROCO2, AURA17, DARDARIN, LRRK2
Clonality Polyclonal
Host
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), ELISA
2 references available
Catalog no. ABIN268762
Quantity 0.1 mg  (0.5 mg/ml)
Price Product not available in this region.
Shipping to

Additional Information
Application Details Publications Alternatives back to top

Alternative name PARK8 / LRRK2
Gene ID 120892
NCBI Acession XP_058513
Immunogen Synthetic peptide CELAEKMRRTSV, representing the near the C- Terminus of thehuman protein sequence according to XP_058513. Reference Sequence: XP_058513.
Cross-Reactivity Human
Isotype IgG
Description This gene is a member of the leucine-rich repeat kinase family and encodes a proteinwith an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, aDFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40domain. The protein is present largely in the cytoplasm but also associates with themitochondrial outer membrane. Mutations in this gene have been associated withParkinson disease-8. Alternate Names: anti-LRRK2 antibody, anti-PARK8 antibody, anti-ROCO2 antibody, anti-FLJ45829antibody, anti-DKFZp434H2111 antibody, anti-leucine-rich repeat kinase 2 antibody,anti-dardarin antibody, anti-Parkinson disease (autosomal dominant) 8 antibody.
Specificity Species Reactivity: Human. Other species not tested.

Application Details
Publications Alternatives back to top

Application Notes Suggested working dilutions: ELISA 1:64000,Western Blot
Concentration 0.5 mg/ml
Purification Aff - Purified
Buffer Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Paisán-Ruíz, Jain, Evans et al.: "Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease." in: Neuron, Vol. 44, Issue 4, pp. 595-600, 2004 (PubMed).

Alegre-Abarrategui, Ansorge, Esiri et al.: "LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease." in: Neuropathology and applied neurobiology, Vol. 34, Issue 3, pp. 272-83, 2008 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Leucine-Rich Repeat Kinase 2 (LRRK2)", type "Antibodies"
Hosts Rabbit (74), Mouse (11), Goat (5), Sheep (3)
Reactivities Human (85), Mouse (Murine) (43), Cow (Bovine) (38), Rat (Rattus) (37), Dog (Canine) (18), Horse (Equine) (18), Pig (Porcine) (18), Rabbit (18)
Applications Western Blotting (WB) (59), Immunofluorescence (IF) (37), ELISA (35), Immunohistochemistry (IHC) (19), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (19), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunoprecipitation (IP) (4), Immunostaining (ISt) (4), Immunoelectron Microscopy (IEM) (3), Immunocytochemistry (ICC) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Immunohistochemistry (Fixed) (IHC (fx)) (1), Radioimmunoassay (RIA) (1)
Conjugates Biotin (3), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes pThr1410 (18), C-Term (8), Glu519 (2), Leu893 (2), Leu899 (2), Leu955 (2), N-Term (2), AA 1838-2133 (1), AA 2506-2522 (1), AA 945-960 (1), AA 946-962 (1), Internal Region (1)