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Details for Product No. ABIN268840

Scavenger Receptor Class B, Member 1 (SCARB1) antibody

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Synonyms CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1, AI120173, CD36, Cd36l1, Cla-1, Cla1, D5Ertd460e, Hdlq1, Hlb398, SR-B1, SRBI, Srb1, mSR-BI, cb1015, SCARB1, Scarb1
»Alternatives Human, Mouse (Murine), Rat (Rattus), Mustelid
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN268840
Quantity 25 µL
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Immunogen A peptide containing residues 496-509 from mouse SR-BI plus an N-terminal cysteinewas coupled to KLH. CSPAAKGTVLQEAKL-COOH.
Specificity 400-101 is specific for the SR-BI. Species Reactivity: Reacts with mouse, rat human and hamster SR-BI. Localization: Cell Membrane, multi-pass membrane protein.
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Serum
Alternative Name SCARB1
Background High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and theirplasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BIbinds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDLwith high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues,and mediates selective cholesterol uptake by a distinct mechanism.In mice, it seems that SR-BI plays a key role in determining the levels of plasmalipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland. Alternate Names: anti-SCARB1 antibody, anti-SR-B1 antibody, anti-SR-BI antibody, anti-ScavengerReceptor-BI antibody, anti-Scavenger Receptor-B1 antibody. Related Diseases: Cancer, Coronary Artery Disease, Atherosclerosis
Gene ID 949
Application Notes immunoprecipitation 4-8 ug/ml lysate,Western Blot 1:1000
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Wang, Silver, Costet et al.: "Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1." in: The Journal of biological chemistry, Vol. 275, Issue 42, pp. 33053-8, 2000 (PubMed).

Zhang, Ahmed, McFarlane et al.: "Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways." in: Journal of lipid research, Vol. 48, Issue 2, pp. 405-16, 2007 (PubMed).

Alternatives for antigen "Scavenger Receptor Class B, Member 1 (SCARB1)", type "Antibodies"
Hosts (62), (13), (5)
Reactivities (56), (53), (45), (17), (17), (17), (7), (4), (2), (2)
Applications (58), (25), (23), (19), (17), (17), (15), (10), (10), (7), (5), (2), (2), (1)
Conjugates (5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (12), (5), (3), (2), (1)