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Details for Product No. ABIN268842

Scavenger Receptor Class B, Member 2 (SCARB2) antibody

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Synonyms AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII, Cd36l2, MLGP85, 9330185J12Rik, LimpII, cd36l2, fi13c07, chunp6914, wu:fi13c07, SCARB2, scarb2
»Alternatives Cow (Bovine), Hamster, Human, Mouse (Murine), Rat (Rattus), Mustelid
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 7 references available
Catalog no. ABIN268842
Quantity 25 µL
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Immunogen A peptide containing residues from mouse SR-BII (2).
Specificity 400-102 is specific for the SR-BII. Species Reactivity: Mouse, rat, bovine, human, mink and hamster SR-BII. Localization: Lysosomal membrane.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Alternative Name SCARB2
Background High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and theirplasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI andSR-BII (previously known as SR-BI.2) are the alternatively spliced products of a singlegene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain isalmost completely different. SR-BII binds HDLs and mediates selective uptake of HDLcholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressingSR-BI, with SR-BII expression found in liver, adrenal glands, and testes.Although the role of SR-BII is not completely clear, research suggests that it may be afunctional HDL receptor. In addition, SR-BII mRNA results from the alternative splicingof SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer oflipid between HDL and cells. The relative expression and functional activities of thesetwo isoforms create a potential means of regulating selective lipid transfer between HDLand cells. (1-6). Alternate Names: anti-SR-B2 antibody, anti-SR-BII antibody, anti-Scavenger Receptor-BII antibody,anti-Scavenger Receptor-B2 antibody. Related Diseases: Cancer
Application Notes Suggested working dilutions: immunofluorescence 1/500 - 1/1000,Western Blot 1/1000,Immunohistochemistry-Paraffin 1/25
Restrictions For Research Use only
Format Liquid
Buffer serum. Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage -20 °C
Rigotti, Trigatti, Penman et al.: "A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 23, pp. 12610-5, 1997 (PubMed).

Krieger: "The "best" of cholesterols, the "worst" of cholesterols: a tale of two receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 8, pp. 4077-80, 1998 (PubMed).

Wadsack, Hirschmugl, Hammer et al.: "Scavenger receptor class B, type I on non-malignant and malignant human epithelial cells mediates cholesteryl ester-uptake from high density lipoproteins." in: The international journal of biochemistry & cell biology, Vol. 35, Issue 4, pp. 441-54, 2003 (PubMed).

Kocher, Yesilaltay, Cirovic et al.: "Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism." in: The Journal of biological chemistry, Vol. 278, Issue 52, pp. 52820-5, 2003 (PubMed).

Akpovi, Yoon, Vitale et al.: "The predominance of one of the SR-BI isoforms is associated with increased esterified cholesterol levels not apoptosis in mink testis." in: Journal of lipid research, Vol. 47, Issue 10, pp. 2233-47, 2006 (PubMed).

Huby, Doucet, Dachet et al.: "Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues." in: The Journal of clinical investigation, Vol. 116, Issue 10, pp. 2767-76, 2006 (PubMed).

Barth, Schnober, Neumann-Haefelin et al.: "Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells." in: Journal of virology, Vol. 82, Issue 7, pp. 3466-79, 2008 (PubMed).

Alternatives for antigen "Scavenger Receptor Class B, Member 2 (SCARB2)", type "Antibodies"
Hosts (40), (7), (5)
Reactivities (46), (25), (15), (5), (5), (2), (1), (1), (1)
Applications (48), (26), (17), (15), (11), (8), (6), (1), (1)
Epitopes (12), (6), (4), (3), (2), (1), (1)