ABCA1 antibody (ATP-Binding Cassette, Sub-Family A (ABC1), Member 1) (AA 1100-1300) (Biotin)

Details for Product anti-ABCA1 Antibody No. ABIN268847, Supplier: Log in to see
Antigen
  • ABC-1
  • ABC1
  • CERP
  • HDLDT1
  • TGD
  • ABCA1
  • Abc1
  • ATP-binding cassette A1
  • Arabidopsis thaliana ATP-binding cassette A1
  • AtABCA1
  • ATP-binding cassette, sub-family A (ABC1), member 1
  • ATP-binding cassette, subfamily A (ABC1), member 1
  • ABC transporter A family member 1
  • ABCA1
  • Abca1
  • abca1
Alternatives
anti-Human ABCA1 antibody for Immunocytochemistry
Epitope
AA 1100-1300
25
21
19
16
15
12
11
6
5
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Hamster, Human, Mouse (Murine), Mustelid, Pig (Porcine), Rat (Rattus)
163
145
89
21
18
14
14
14
12
3
2
2
1
1
Host
Rabbit
110
59
22
4
Clonality
Polyclonal
Conjugate
This ABCA1 antibody is conjugated to Biotin
13
8
8
8
6
6
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5
4
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
114
78
50
40
39
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37
26
20
12
4
3
2
2
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Partial peptide sequence (within residues 1100-1300) of human ABCA1 [UniProt# O95477]. Actual immunogen sequence is proprietary information.
Purification Immunogen affinity purified
Alternative Name ABCA1 (ABCA1 Antibody Abstract)
Background Gene Symbol: ABCA1
Molecular Weight Theoretical MW: 220 kDa
Gene ID 19
UniProt O95477
Pathways Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Lipid Metabolism by PPARalpha
Application Notes Western Blot, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-FrozenThis ABCA1 antibody is useful for Western blot and Immunohistochemistry on frozen and paraffin embedded sections. In Western blot a band representing ABCA1 is observed at ~220 kDa. Additional non-specific bands are seen at lower molecular weights, but do not interfere with the ABCA1 signal. ELISA has been reported in scientific literature. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Buffer PBS
Buffer contains: 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C in the dark.
Product cited in: Basso, Freeman, Knapper, Remaley, Stonik, Neufeld, Tansey, Amar, Fruchart-Najib, Duverger, Santamarina-Fojo, Brewer: "Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations." in: Journal of lipid research, Vol. 44, Issue 2, pp. 296-302, 2003 (PubMed).

Wang, Chen, Linsel-Nitschke, Martinez, Agerholm-Larsen, Silver, Tall: "A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I." in: The Journal of clinical investigation, Vol. 111, Issue 1, pp. 99-107, 2003 (PubMed).

Escher, Krozowski, Croft, Sviridov: "Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux." in: The Journal of biological chemistry, Vol. 278, Issue 13, pp. 11015-9, 2003 (PubMed).

Koldamova, Lefterov, Ikonomovic, Skoko, Lefterov, Isanski, DeKosky, Lazo: "22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion." in: The Journal of biological chemistry, Vol. 278, Issue 15, pp. 13244-56, 2003 (PubMed).

Sun, Yao, Kim, Tall: "Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion." in: The Journal of biological chemistry, Vol. 278, Issue 30, pp. 27688-94, 2003 (PubMed).

Le Lay, Robichon, Le Liepvre, Dagher, Ferre, Dugail: "Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells." in: Journal of lipid research, Vol. 44, Issue 8, pp. 1499-507, 2003 (PubMed).

Khovidhunkit, Moser, Shigenaga, Grunfeld, Feingold: "Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR." in: Journal of lipid research, Vol. 44, Issue 9, pp. 1728-36, 2003 (PubMed).

Witting, Maiorano, Davidson: "Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1." in: The Journal of biological chemistry, Vol. 278, Issue 41, pp. 40121-7, 2003 (PubMed).

Burgess, Kiss, Zheng, Zachariah, Marcel: "Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux." in: The Journal of biological chemistry, Vol. 277, Issue 35, pp. 31318-26, 2002 (PubMed).

Murthy, Born, Mathur, Field: "LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells." in: Journal of lipid research, Vol. 43, Issue 7, pp. 1054-64, 2002 (PubMed).

Feng, Tabas: "ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity." in: The Journal of biological chemistry, Vol. 277, Issue 45, pp. 43271-80, 2002 (PubMed).

Fukumoto, Deng, Irizarry, Fitzgerald, Rebeck: "Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels." in: The Journal of biological chemistry, Vol. 277, Issue 50, pp. 48508-13, 2002 (PubMed).

Background publications Terasaka, Hiroshima, Koieyama, Ubukata, Morikawa, Nakai, Inaba: "T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice." in: FEBS letters, Vol. 536, Issue 1-3, pp. 6-11, 2003 (PubMed).

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