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ABCA1 antibody (ATP-Binding Cassette, Sub-Family A (ABC1), Member 1) (AA 1100-1300) (Biotin)

Details for Product anti-ABCA1 Antibody No. ABIN268847, Supplier: Log in to see
Antigen
  • ABC-1
  • ABC1
  • Abc1
  • ABCA1
  • CERP
  • HDLDT1
  • TGD
Epitope
AA 1100-1300
19
18
14
13
11
10
6
5
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Hamster, Human, Mouse (Murine), Mustelid, Pig (Porcine), Rat (Rattus)
117
110
69
17
14
12
12
12
12
Host
Rabbit
84
41
25
3
Clonality
Polyclonal
Conjugate
This ABCA1 antibody is conjugated to Biotin
14
7
6
6
5
4
3
3
3
3
3
3
3
2
2
2
2
2
2
1
Application
ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
88
56
42
38
31
23
22
21
15
14
3
2
1
1
1
Supplier
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Immunogen Partial peptide sequence (within residues 1100-1300) of human ABCA1 [UniProt# O95477]. Actual immunogen sequence is proprietary information.
Cross-Reactivity (Details) Canine reactivity reported in scientific literature (PMID: 24612239)
Purification Immunogen affinity purified
Alternative Name ABCA1 (ABCA1 Antibody Abstract)
Background Gene Symbol: ABCA1
Molecular Weight Theoretical MW: 220 kDa
Gene ID 19, 11303, 313210
UniProt O95477
Application Notes Western Blot 1:500, ELISA, Immunohistochemistry 1:200, Immunohistochemistry-Paraffin 1:200, Immunohistochemistry-Frozen
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Buffer PBS
Buffer contains: 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C in the dark.
Product cited in: Basso, Freeman, Knapper, Remaley, Stonik, Neufeld, Tansey, Amar, Fruchart-Najib, Duverger, Santamarina-Fojo, Brewer: "Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations." in: Journal of lipid research, Vol. 44, Issue 2, pp. 296-302, 2003 (PubMed).

Wang, Chen, Linsel-Nitschke, Martinez, Agerholm-Larsen, Silver, Tall: "A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I." in: The Journal of clinical investigation, Vol. 111, Issue 1, pp. 99-107, 2003 (PubMed).

Escher, Krozowski, Croft, Sviridov: "Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux." in: The Journal of biological chemistry, Vol. 278, Issue 13, pp. 11015-9, 2003 (PubMed).

Koldamova, Lefterov, Ikonomovic, Skoko, Lefterov, Isanski, DeKosky, Lazo: "22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion." in: The Journal of biological chemistry, Vol. 278, Issue 15, pp. 13244-56, 2003 (PubMed).

Sun, Yao, Kim, Tall: "Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion." in: The Journal of biological chemistry, Vol. 278, Issue 30, pp. 27688-94, 2003 (PubMed).

Le Lay, Robichon, Le Liepvre, Dagher, Ferre, Dugail: "Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells." in: Journal of lipid research, Vol. 44, Issue 8, pp. 1499-507, 2003 (PubMed).

Khovidhunkit, Moser, Shigenaga, Grunfeld, Feingold: "Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR." in: Journal of lipid research, Vol. 44, Issue 9, pp. 1728-36, 2003 (PubMed).

Witting, Maiorano, Davidson: "Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1." in: The Journal of biological chemistry, Vol. 278, Issue 41, pp. 40121-7, 2003 (PubMed).

Burgess, Kiss, Zheng, Zachariah, Marcel: "Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux." in: The Journal of biological chemistry, Vol. 277, Issue 35, pp. 31318-26, 2002 (PubMed).

Murthy, Born, Mathur, Field: "LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells." in: Journal of lipid research, Vol. 43, Issue 7, pp. 1054-64, 2002 (PubMed).

Feng, Tabas: "ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity." in: The Journal of biological chemistry, Vol. 277, Issue 45, pp. 43271-80, 2002 (PubMed).

Fukumoto, Deng, Irizarry, Fitzgerald, Rebeck: "Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels." in: The Journal of biological chemistry, Vol. 277, Issue 50, pp. 48508-13, 2002 (PubMed).

Background publications Terasaka, Hiroshima, Koieyama, Ubukata, Morikawa, Nakai, Inaba: "T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice." in: FEBS letters, Vol. 536, Issue 1-3, pp. 6-11, 2003 (PubMed).

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